DICP OpenIR
Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules
Xie, Hong G.1,2; Zheng, Jia N.1,2; Li, Xiao X.1,2; Liu, Xiu D.3; Zhu, Jing1; Wang, Feng4; Xie, Wei Y.1; Ma, Xiao J.1; Ma XJ(马小军)
Source PublicationLANGMUIR
2010-04-20
DOI10.1021/la903874g
Volume26Issue:8Pages:5587-5594
Indexed BySCI
SubtypeArticle
Department18
Funding Project1802
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS Research AreaChemistry ; Materials Science
WOS KeywordALGINATE GEL BEADS ; POLYELECTROLYTE MULTILAYER FILMS ; NANOMETER-SCALE ROUGHNESS ; SELF-ASSEMBLED MONOLAYERS ; PROTEIN ADSORPTION ; SECONDARY STRUCTURE ; CALCIUM-ALGINATE ; PLATELET-ADHESION ; SERUM-ALBUMIN ; CHITOSAN
AbstractWe report the influence of surface morphology and charge of alginate/chitosan (ACA) microcapsules on both the amount of adsorbed protein and its secondary structural changes during adsorption. Variations in surface morphology and charge were controlled by varying alginate molecular weight and chitosan concentration. Plasma fibrinogen (Fgn) was chosen to model this adsorption to foreign surfaces. The surface of ACA microcapsules exhibited a granular structure after incubating calcium alginate beads with chitosan solution to form membranes. The surface roughness of ACA microcapsule membranes decreased with decreasing alginate molecular weight and chitosan concentration. Zeta potential measurements showed that there was a net negative charge on the surface of ACA microcapsules which decreased with decreasing alginate molecular weight and chitosan concentration. The increase in both surface roughness and zeta potential resulted in an increase in the amount of Fgn adsorbed. Moreover, the higher the zeta potential was, the stronger the protein-surface interaction between fibrinogen and ACA microcapsules was. More protein molecules adsorbed spread and had a greater conformational change on rougher surfaces for more surfaces being available for protein to attach.
Language英语
URL查看原文
WOS IDWOS:000276562300042
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/103189
Collection中国科学院大连化学物理研究所
Corresponding AuthorMa XJ(马小军)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Opt Fabricat & Coating, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Xie, Hong G.,Zheng, Jia N.,Li, Xiao X.,et al. Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules[J]. LANGMUIR,2010,26(8):5587-5594.
APA Xie, Hong G..,Zheng, Jia N..,Li, Xiao X..,Liu, Xiu D..,Zhu, Jing.,...&马小军.(2010).Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules.LANGMUIR,26(8),5587-5594.
MLA Xie, Hong G.,et al."Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules".LANGMUIR 26.8(2010):5587-5594.
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