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Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules
Xie, Hong G.1,2; Zheng, Jia N.1,2; Li, Xiao X.1,2; Liu, Xiu D.3; Zhu, Jing1; Wang, Feng4; Xie, Wei Y.1; Ma, Xiao J.1; Ma XJ(马小军)
刊名LANGMUIR
2010-04-20
DOI10.1021/la903874g
26期:8页:5587-5594
收录类别SCI
文章类型Article
部门归属18
项目归属1802
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences ; Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Materials Science
关键词[WOS]ALGINATE GEL BEADS ; POLYELECTROLYTE MULTILAYER FILMS ; NANOMETER-SCALE ROUGHNESS ; SELF-ASSEMBLED MONOLAYERS ; PROTEIN ADSORPTION ; SECONDARY STRUCTURE ; CALCIUM-ALGINATE ; PLATELET-ADHESION ; SERUM-ALBUMIN ; CHITOSAN
英文摘要We report the influence of surface morphology and charge of alginate/chitosan (ACA) microcapsules on both the amount of adsorbed protein and its secondary structural changes during adsorption. Variations in surface morphology and charge were controlled by varying alginate molecular weight and chitosan concentration. Plasma fibrinogen (Fgn) was chosen to model this adsorption to foreign surfaces. The surface of ACA microcapsules exhibited a granular structure after incubating calcium alginate beads with chitosan solution to form membranes. The surface roughness of ACA microcapsule membranes decreased with decreasing alginate molecular weight and chitosan concentration. Zeta potential measurements showed that there was a net negative charge on the surface of ACA microcapsules which decreased with decreasing alginate molecular weight and chitosan concentration. The increase in both surface roughness and zeta potential resulted in an increase in the amount of Fgn adsorbed. Moreover, the higher the zeta potential was, the stronger the protein-surface interaction between fibrinogen and ACA microcapsules was. More protein molecules adsorbed spread and had a greater conformational change on rougher surfaces for more surfaces being available for protein to attach.
语种英语
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WOS记录号WOS:000276562300042
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/103189
专题中国科学院大连化学物理研究所
通讯作者Ma XJ(马小军)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Opt Fabricat & Coating, Dalian 116023, Peoples R China
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GB/T 7714
Xie, Hong G.,Zheng, Jia N.,Li, Xiao X.,et al. Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules[J]. LANGMUIR,2010,26(8):5587-5594.
APA Xie, Hong G..,Zheng, Jia N..,Li, Xiao X..,Liu, Xiu D..,Zhu, Jing.,...&马小军.(2010).Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules.LANGMUIR,26(8),5587-5594.
MLA Xie, Hong G.,et al."Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules".LANGMUIR 26.8(2010):5587-5594.
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