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题名: Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules
作者: Xie, Hong G.1, 2;  Zheng, Jia N.1, 2;  Li, Xiao X.1, 2;  Liu, Xiu D.3;  Zhu, Jing1;  Wang, Feng4;  Xie, Wei Y.1;  Ma, Xiao J.1
通讯作者: 马小军
刊名: LANGMUIR
发表日期: 2010-04-20
DOI: 10.1021/la903874g
卷: 26, 期:8, 页:5587-5594
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1802
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Multidisciplinary ;  Chemistry, Physical ;  Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ;  Materials Science
英文摘要: We report the influence of surface morphology and charge of alginate/chitosan (ACA) microcapsules on both the amount of adsorbed protein and its secondary structural changes during adsorption. Variations in surface morphology and charge were controlled by varying alginate molecular weight and chitosan concentration. Plasma fibrinogen (Fgn) was chosen to model this adsorption to foreign surfaces. The surface of ACA microcapsules exhibited a granular structure after incubating calcium alginate beads with chitosan solution to form membranes. The surface roughness of ACA microcapsule membranes decreased with decreasing alginate molecular weight and chitosan concentration. Zeta potential measurements showed that there was a net negative charge on the surface of ACA microcapsules which decreased with decreasing alginate molecular weight and chitosan concentration. The increase in both surface roughness and zeta potential resulted in an increase in the amount of Fgn adsorbed. Moreover, the higher the zeta potential was, the stronger the protein-surface interaction between fibrinogen and ACA microcapsules was. More protein molecules adsorbed spread and had a greater conformational change on rougher surfaces for more surfaces being available for protein to attach.
关键词[WOS]: ALGINATE GEL BEADS ;  POLYELECTROLYTE MULTILAYER FILMS ;  NANOMETER-SCALE ROUGHNESS ;  SELF-ASSEMBLED MONOLAYERS ;  PROTEIN ADSORPTION ;  SECONDARY STRUCTURE ;  CALCIUM-ALGINATE ;  PLATELET-ADHESION ;  SERUM-ALBUMIN ;  CHITOSAN
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000276562300042
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/103189
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Opt Fabricat & Coating, Dalian 116023, Peoples R China

Recommended Citation:
Xie, Hong G.,Zheng, Jia N.,Li, Xiao X.,et al. Effect of Surface Morphology and Charge on the Amount and Conformation of Fibrinogen Adsorbed onto Alginate/Chitosan Microcapsules[J]. LANGMUIR,2010,26(8):5587-5594.
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