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题名: Rapid Qualitative and Quantitative Determination of Seven Valuable Taxanes from Various Taxus Species by UFLC-ESI-MS and UFLC-DAD
作者: Ge, Guang-Bo1, 2;  Liang, Si-Cheng1;  Hu, Ying1;  Liu, Xing-Bao1;  Mao, Yu-Xi1, 2;  Zhang, Yan-Yan1, 2;  Luan, Hong-Wei1;  Qiu, Ming-Hua3;  Yang, Ling1
通讯作者: 杨凌
关键词: Taxaceae ;  Taxus ;  yew ;  taxane ;  paclitaxel ;  target analysis
刊名: PLANTA MEDICA
发表日期: 2010-10-01
DOI: 10.1055/s-0030-1249959
卷: 76, 期:15, 页:1773-1777
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: The distribution and level of yew constituents vary with species and tissues. In this study, a rapid and valid method incorporating ultra-fast liquid chromatography (UFLC) with MS and UV detection was developed for simultaneous determination of paclitaxel and its six semisynthesis precursors in needles and hair roots from various Taxus species. All target analytes could be identified by comparing their retention times as well as UV and MS spectra with authentic standards, while seven valuable taxanes in botanical samples can be rapidly determined by UFLC-DAD with excellent sensitivity. Analysis of more than one hundred yew samples from nine species showed significant variations in distribution and content of seven evaluated taxanes. Thus, different developmental schemes should be used for better utilization of various yew resources.
关键词[WOS]: IONIZATION MASS-SPECTROMETRY ;  BASIC TAXOID CONTENTS ;  LIQUID-CHROMATOGRAPHY ;  PACLITAXEL ;  EFFICIENT ;  DITERPENOIDS ;  CONVERSION ;  NEEDLES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000283917300028
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/103349
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming, Peoples R China

Recommended Citation:
Ge, Guang-Bo,Liang, Si-Cheng,Hu, Ying,et al. Rapid Qualitative and Quantitative Determination of Seven Valuable Taxanes from Various Taxus Species by UFLC-ESI-MS and UFLC-DAD[J]. PLANTA MEDICA,2010,76(15):1773-1777.
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