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Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems
Kapoor, Mahendra P.1; Vinu, Ajayan2; Fujii, Wataru1; Kimura, Tatsuo3; Yang, Qihua4; Kasama, Yuuki1; Yanagi, Masaaki1; Juneja, Lekh R.1; Mahendra P. Kapoor
KeywordSelf-assembly Hollow Microspheres Emulsifiers Food Grade Delivery Systems
Source PublicationMICROPOROUS AND MESOPOROUS MATERIALS
2010-03-01
DOI10.1016/j.micromeso.2009.08.019
Volume128Issue:1-3Pages:187-193
Indexed BySCI
SubtypeArticle
Department5
Funding Project506
Contribution Rank4;5
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Applied ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS KeywordDRUG-DELIVERY ; RELEASE ; SPHERES ; NANOPARTICLES ; PARTICLES ; MOLECULES ; MECHANISM ; CARRIERS
AbstractRandomly ordered mesoporous silicas hollow microspheres of 20-50 mu m in diameter with distinguished characteristic of interconnected porosity (7-14 nm) of their thin outer walls are developed. Food grade emulsifier polyglycerol esters of fatty acids (PGEFA) are used as a soft-template and n-decane as a swelling agent, which was necessary for the formation of silica doped micelles to improve the mesoporous channel orientation without leading the phase transition. The interconnected pore channels that extend from the outside of the microspheres shell to its inside are used to fill the mesoporous silicas microspheres for enhanced encapsulation of VB(3) precursor and cumulative in vitro release of vitamin B(3) with considerable rate pharmacokinetics using simple pH trigger mechanism for the delivery systems. (C) 2009 Elsevier Inc. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000273105800025
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/103477
Collection中国科学院大连化学物理研究所
Corresponding AuthorMahendra P. Kapoor
Affiliation1.Taiyo Kagaku Co Ltd, Res & Dev, Yokaichi, Mie 5100844, Japan
2.Natl Inst Mat Sci, World Premier Int Res Ctr Mat Nanoarchitecton MAN, Tsukuba, Ibaraki 3050044, Japan
3.Natl Inst Adv Ind Sci & Technol, Adv Mfg Res Inst, Moriyama Ku, Nagoya, Aichi 4638560, Japan
4.Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Kapoor, Mahendra P.,Vinu, Ajayan,Fujii, Wataru,et al. Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems[J]. MICROPOROUS AND MESOPOROUS MATERIALS,2010,128(1-3):187-193.
APA Kapoor, Mahendra P..,Vinu, Ajayan.,Fujii, Wataru.,Kimura, Tatsuo.,Yang, Qihua.,...&Mahendra P. Kapoor.(2010).Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems.MICROPOROUS AND MESOPOROUS MATERIALS,128(1-3),187-193.
MLA Kapoor, Mahendra P.,et al."Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems".MICROPOROUS AND MESOPOROUS MATERIALS 128.1-3(2010):187-193.
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