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题名: Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems
作者: Kapoor, Mahendra P.1;  Vinu, Ajayan2;  Fujii, Wataru1;  Kimura, Tatsuo3;  Yang, Qihua4;  Kasama, Yuuki1;  Yanagi, Masaaki1;  Juneja, Lekh R.1
通讯作者: Mahendra P. Kapoor
关键词: Self-assembly ;  Hollow microspheres ;  Emulsifiers ;  Food grade ;  Delivery systems
刊名: MICROPOROUS AND MESOPOROUS MATERIALS
发表日期: 2010-03-01
DOI: 10.1016/j.micromeso.2009.08.019
卷: 128, 期:1-3, 页:187-193
收录类别: SCI
文章类型: Article
部门归属: 5
项目归属: 506
产权排名: 4;5
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Applied ;  Chemistry, Physical ;  Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ;  Science & Technology - Other Topics ;  Materials Science
英文摘要: Randomly ordered mesoporous silicas hollow microspheres of 20-50 mu m in diameter with distinguished characteristic of interconnected porosity (7-14 nm) of their thin outer walls are developed. Food grade emulsifier polyglycerol esters of fatty acids (PGEFA) are used as a soft-template and n-decane as a swelling agent, which was necessary for the formation of silica doped micelles to improve the mesoporous channel orientation without leading the phase transition. The interconnected pore channels that extend from the outside of the microspheres shell to its inside are used to fill the mesoporous silicas microspheres for enhanced encapsulation of VB(3) precursor and cumulative in vitro release of vitamin B(3) with considerable rate pharmacokinetics using simple pH trigger mechanism for the delivery systems. (C) 2009 Elsevier Inc. All rights reserved.
关键词[WOS]: DRUG-DELIVERY ;  RELEASE ;  SPHERES ;  NANOPARTICLES ;  PARTICLES ;  MOLECULES ;  MECHANISM ;  CARRIERS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000273105800025
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/103477
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Taiyo Kagaku Co Ltd, Res & Dev, Yokaichi, Mie 5100844, Japan
2.Natl Inst Mat Sci, World Premier Int Res Ctr Mat Nanoarchitecton MAN, Tsukuba, Ibaraki 3050044, Japan
3.Natl Inst Adv Ind Sci & Technol, Adv Mfg Res Inst, Moriyama Ku, Nagoya, Aichi 4638560, Japan
4.Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Kapoor, Mahendra P.,Vinu, Ajayan,Fujii, Wataru,et al. Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems[J]. MICROPOROUS AND MESOPOROUS MATERIALS,2010,128(1-3):187-193.
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