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题名: Selective extraction of sulfonamides from food by use of silica-coated molecularly imprinted polymer nanospheres
作者: Gao, Ruixia1;  Zhang, Junjie2;  He, Xiwen1;  Chen, Langxing1;  Zhang, Yukui1, 3
通讯作者: 张玉奎
关键词: Molecularly imprinted polymers ;  Nanospheres ;  Sulfonamide antibiotics ;  Adsorbents ;  High-performance liquid chromatography
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2010-09-01
DOI: 10.1007/s00216-010-3909-z
卷: 398, 期:1, 页:451-461
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1810
产权排名: 5;2
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: We report the use of nanospheres prepared by coating silica with molecularly imprinted polymer (MIP) for sulfamethoxazole (SMO). The resulting SiO(2)-SMO-MIP nanoparticles have highly improved imprinting and adsorption capacity, and can be used for separation and determination of sulfonamides in eggs and milk. In the synthesis, monodispersed SiO(2) nanoparticles (Si-NP) of diameter 80 nm were amino-modified by reaction with 3-aminopropyltriethoxylsilane. The acryloyl monolayer was then grafted onto the amine-modified Si-NP. Finally, the MIP films were coated onto the surface of Si-NP by the copolymerization of the vinyl end groups with functional monomer (acrylamide), cross-linking agent (ethylene glycol dimethacrylate), initiator (azo-bis-isobutyronitrile), and template molecule (sulfamethoxazole). The resulting SiO(2)-SMO-MIP-NP were characterized by transmission electron microscopy, scanning electron microscopy, and Fourier transform infrared spectrometry. The adsorption properties were demonstrated by equilibrium rebinding experiments and Scatchard analysis. The results showed that the binding sites of the SiO(2)-SMO-MIP were highly accessible, and the maximum adsorption capacity of the SiO(2)-SMO-MIP for SMO was 20.21 mg g(-1). The selectivity of the SiO(2)-SMO-MIP-NP obtained was elucidated by using SMO and structurally related sulfonamides. The results indicated that the SiO(2)-SMO-MIP had significant selectivity for SMO. The feasibility of removing SMO and sulfadiazine (SDZ) from food samples was proved by use of spiked milk and eggs. A method for the separation and determination of trace SMO and SDZ in milk and egg samples was developed, with recoveries ranging from 69.8% to 89.1%.
关键词[WOS]: SOLID-PHASE EXTRACTION ;  PERFORMANCE LIQUID-CHROMATOGRAPHY ;  INIFERTER-MODIFIED SUPPORTS ;  MASS-SPECTROMETRY ;  CAPILLARY-ELECTROPHORESIS ;  FUNCTIONAL MONOMERS ;  PROTEIN RECOGNITION ;  SURFACE ;  NANOPARTICLES ;  RESIDUES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000280807500037
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/103565
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
2.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Gao, Ruixia,Zhang, Junjie,He, Xiwen,et al. Selective extraction of sulfonamides from food by use of silica-coated molecularly imprinted polymer nanospheres[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2010,398(1):451-461.
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