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Recent advances in proteolysis and peptide/protein separation by chromatographic strategies
Zhang XiangMin1,2; Liu BaoHong1,2; Zhang LiHua3; Zou HanFa3; Cao Jing1,2; Gao MingXia1,2; Tang Jia1,2; Liu Yun1,2; Yang PengYuan1,2; Zhang YuKui3; Liu Y(刘云); Zhang YK(张玉奎)
关键词Proteolysis Enzymatic Digestion Chromatographic Separation Peptide Enrichment Mass Spectrometry
刊名SCIENCE CHINA-CHEMISTRY
2010-04-01
DOI10.1007/s11426-010-0135-7
53期:4页:685-694
收录类别SCI
文章类型Review
部门归属18
项目归属1810
产权排名3;2
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]TANDEM MASS-SPECTROMETRY ; MULTIDIMENSIONAL LIQUID-CHROMATOGRAPHY ; HIGHLY EFFICIENT PROTEOLYSIS ; MONOLITHIC ENZYMATIC MICROREACTOR ; IMMOBILIZED TRYPSIN MICROREACTOR ; PEPTIDE-MAPPING ANALYSIS ; EXCHANGE TRAP COLUMN ; LC-ESI-MS/MS ; PROTEOME ANALYSIS ; HUMAN PLASMA
英文摘要This review gives a broad glance on the progress of recent advances on proteolysis and peptide/protein separation by chromatographic strategies in the past ten years, covering the main research in these areas especially in China. The reviewed research focused on enzymatic micro-reactors and peptide separation in bottom-up approaches, and protein and peptide separation in top-down approaches. The new enzymatic micro-reactor is able to accelerate proteolytic reaction rate from conventionally a couple of hours to a few seconds, and the multiple dimensional chromatographic-separation with various models or arrays could sufficiently separate the proteomic mixture. These advances have significantly promoted the research of protein/peptide separation and identification in proteomics.
语种英语
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WOS记录号WOS:000278263400002
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/103569
专题中国科学院大连化学物理研究所
通讯作者Liu Y(刘云); Zhang YK(张玉奎)
作者单位1.Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
2.Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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Zhang XiangMin,Liu BaoHong,Zhang LiHua,et al. Recent advances in proteolysis and peptide/protein separation by chromatographic strategies[J]. SCIENCE CHINA-CHEMISTRY,2010,53(4):685-694.
APA Zhang XiangMin.,Liu BaoHong.,Zhang LiHua.,Zou HanFa.,Cao Jing.,...&张玉奎.(2010).Recent advances in proteolysis and peptide/protein separation by chromatographic strategies.SCIENCE CHINA-CHEMISTRY,53(4),685-694.
MLA Zhang XiangMin,et al."Recent advances in proteolysis and peptide/protein separation by chromatographic strategies".SCIENCE CHINA-CHEMISTRY 53.4(2010):685-694.
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