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Development of Identification for Post-Translational Modifications in Histones by Mass Spectrometry Based Proteomics
Chen Ying1; Zhang Kai1; He Xiwen1; Zhang Yukui1,2
关键词Histone Post-translational Modifications (Ptms) Mass Spectrometry High Prerormance Liquid Chromatography (Hplc)
刊名PROGRESS IN CHEMISTRY
2010-04-01
22期:4页:713-719
收录类别SCI
文章类型Article
部门归属18
项目归属1810
产权排名4;2
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]ELECTRON-TRANSFER DISSOCIATION ; H3 LYSINE-56 ACETYLATION ; TOP-DOWN PROTEOMICS ; H1 ISOFORMS ; CELL-CYCLE ; CHICKEN ERYTHROCYTES ; DYNAMIC CHANGES ; GLOBAL CHANGES ; CORE HISTONES ; AMINO-ACIDS
英文摘要In eukaryotic cells, chromosomal DNA is packaged into a compact structure, chromatin, with the help of four core histones. The fundamental repeating unit of chromatin is the nucleosome, which contains an octamer of core histones, around 147 base pairs of DNA are wrapped. Post-translational modifications (PTMs) in histones are generally considered to be a major group of epigenetic marks. Accordingly, because PTMs alter the properties of histones, hence affect chromatin structure and function and regulate the gene expression. Therefore identification of histone PTMs is the key to discover histone codes. At present, mass spectrometry has become a powerful analysis tool. In this paper we introduced the novel development of the strategies based on mass spectrometry ("bottom-up" and "top-down") in mapping histone PTMs, fragment dissociation technologies such as CID, ECD and ETD. We also reported the application of mass spectrometry in addressing histone PTMs sites, identifying histone variants and quantifying differential expression of these PTMs in cells.
语种英语
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WOS记录号WOS:000276929300018
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/103585
专题中国科学院大连化学物理研究所
通讯作者Zhang Kai
作者单位1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
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Chen Ying,Zhang Kai,He Xiwen,et al. Development of Identification for Post-Translational Modifications in Histones by Mass Spectrometry Based Proteomics[J]. PROGRESS IN CHEMISTRY,2010,22(4):713-719.
APA Chen Ying,Zhang Kai,He Xiwen,&Zhang Yukui.(2010).Development of Identification for Post-Translational Modifications in Histones by Mass Spectrometry Based Proteomics.PROGRESS IN CHEMISTRY,22(4),713-719.
MLA Chen Ying,et al."Development of Identification for Post-Translational Modifications in Histones by Mass Spectrometry Based Proteomics".PROGRESS IN CHEMISTRY 22.4(2010):713-719.
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