DICP OpenIR
Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration
Li, Xiaoxia1,2; Wang, Wei1,2; Wei, Guoqiang3; Wang, Guanxiong4; Zhang, Weiguo3; Ma, Xiaojun1,2; Ma XJ(马小军)
关键词Artificial Nerve Chitosan Fk506 Peripheral Nerve Regeneration
刊名BIOTECHNOLOGY LETTERS
2010-09-01
32期:9页:1333-1337
收录类别SCI
文章类型Article
部门归属18
项目归属1802
产权排名(1;1)
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]RECOVERY ; INJURY ; FILMS ; CELLS ; GAPS
英文摘要Immunophilin ligand FK506 has been treated as adjunct therapy for nerve repair due to its potent neurotrophic and neuroprotective actions. It was hypothesized that FK506 releasing from biodegradable chitosan guide provided better nerve regenerative response than the guide with no FK506. The drug was entrapped in the semi-permeable wall of chitosan guide with the drug-loading of 647 mu g/g. Rat sciatic nerve defect model treated with FK506-releasing chitosan guide showed more mature appearance of myelinated fibers 8 weeks after surgery; furthermore, the motor functional reinnervation occurred, the amplitude and velocity of compound muscle action potentials reached 60% and 73% with respect to the normal. Thus, FK506-releasing chitosan guide should be acted as a long-lasting delivery device of immunosuppressive and neuroregenerative agent for peripheral nerve repair.
语种英语
原文出处查看原文
WOS记录号WOS:000280892800022
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/103657
专题中国科学院大连化学物理研究所
通讯作者Ma XJ(马小军)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Dalian Med Univ, Dept Orthoped, Affiliated Hosp 1, Dalian 116011, Peoples R China
4.Beijing Univ Chem Technol, Sch Chem Engn, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Li, Xiaoxia,Wang, Wei,Wei, Guoqiang,et al. Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration[J]. BIOTECHNOLOGY LETTERS,2010,32(9):1333-1337.
APA Li, Xiaoxia.,Wang, Wei.,Wei, Guoqiang.,Wang, Guanxiong.,Zhang, Weiguo.,...&马小军.(2010).Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration.BIOTECHNOLOGY LETTERS,32(9),1333-1337.
MLA Li, Xiaoxia,et al."Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration".BIOTECHNOLOGY LETTERS 32.9(2010):1333-1337.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Xiaoxia]的文章
[Wang, Wei]的文章
[Wei, Guoqiang]的文章
百度学术
百度学术中相似的文章
[Li, Xiaoxia]的文章
[Wang, Wei]的文章
[Wei, Guoqiang]的文章
必应学术
必应学术中相似的文章
[Li, Xiaoxia]的文章
[Wang, Wei]的文章
[Wei, Guoqiang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。