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题名: Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration
作者: Li, Xiaoxia1, 2;  Wang, Wei1, 2;  Wei, Guoqiang3;  Wang, Guanxiong4;  Zhang, Weiguo3;  Ma, Xiaojun1, 2
通讯作者: 马小军
关键词: Artificial nerve ;  Chitosan ;  FK506 ;  Peripheral nerve regeneration
刊名: BIOTECHNOLOGY LETTERS
发表日期: 2010-09-01
卷: 32, 期:9, 页:1333-1337
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1802
产权排名: (1;1)
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
英文摘要: Immunophilin ligand FK506 has been treated as adjunct therapy for nerve repair due to its potent neurotrophic and neuroprotective actions. It was hypothesized that FK506 releasing from biodegradable chitosan guide provided better nerve regenerative response than the guide with no FK506. The drug was entrapped in the semi-permeable wall of chitosan guide with the drug-loading of 647 mu g/g. Rat sciatic nerve defect model treated with FK506-releasing chitosan guide showed more mature appearance of myelinated fibers 8 weeks after surgery; furthermore, the motor functional reinnervation occurred, the amplitude and velocity of compound muscle action potentials reached 60% and 73% with respect to the normal. Thus, FK506-releasing chitosan guide should be acted as a long-lasting delivery device of immunosuppressive and neuroregenerative agent for peripheral nerve repair.
关键词[WOS]: RECOVERY ;  INJURY ;  FILMS ;  CELLS ;  GAPS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000280892800022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/103657
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Dalian Med Univ, Dept Orthoped, Affiliated Hosp 1, Dalian 116011, Peoples R China
4.Beijing Univ Chem Technol, Sch Chem Engn, Beijing 100029, Peoples R China

Recommended Citation:
Li, Xiaoxia,Wang, Wei,Wei, Guoqiang,et al. Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration[J]. BIOTECHNOLOGY LETTERS,2010,32(9):1333-1337.
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