Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration
Li, Xiaoxia1,2; Wang, Wei1,2; Wei, Guoqiang3; Wang, Guanxiong4; Zhang, Weiguo3; Ma, Xiaojun1,2; Ma XJ(马小军)
KeywordArtificial Nerve Chitosan Fk506 Peripheral Nerve Regeneration
Indexed BySCI
Funding Project1802
Contribution Rank(1;1)
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiotechnology & Applied Microbiology
WOS Research AreaBiotechnology & Applied Microbiology
AbstractImmunophilin ligand FK506 has been treated as adjunct therapy for nerve repair due to its potent neurotrophic and neuroprotective actions. It was hypothesized that FK506 releasing from biodegradable chitosan guide provided better nerve regenerative response than the guide with no FK506. The drug was entrapped in the semi-permeable wall of chitosan guide with the drug-loading of 647 mu g/g. Rat sciatic nerve defect model treated with FK506-releasing chitosan guide showed more mature appearance of myelinated fibers 8 weeks after surgery; furthermore, the motor functional reinnervation occurred, the amplitude and velocity of compound muscle action potentials reached 60% and 73% with respect to the normal. Thus, FK506-releasing chitosan guide should be acted as a long-lasting delivery device of immunosuppressive and neuroregenerative agent for peripheral nerve repair.
WOS IDWOS:000280892800022
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Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorMa XJ(马小军)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Dalian Med Univ, Dept Orthoped, Affiliated Hosp 1, Dalian 116011, Peoples R China
4.Beijing Univ Chem Technol, Sch Chem Engn, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiaoxia,Wang, Wei,Wei, Guoqiang,et al. Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration[J]. BIOTECHNOLOGY LETTERS,2010,32(9):1333-1337.
APA Li, Xiaoxia.,Wang, Wei.,Wei, Guoqiang.,Wang, Guanxiong.,Zhang, Weiguo.,...&马小军.(2010).Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration.BIOTECHNOLOGY LETTERS,32(9),1333-1337.
MLA Li, Xiaoxia,et al."Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration".BIOTECHNOLOGY LETTERS 32.9(2010):1333-1337.
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