DICP OpenIR
学科主题物理化学
Alginate/chitosan microcapsules prepared by membrane emulsification internal gelation technology and used as drug carriers
Liu XD(刘袖洞); Ma XJ(马小军); Yuan Q(袁权)
会议名称World Congress on Medical Physics and Biomedical Engineering 2003
会议日期2003-8-24
2003-08-24
会议地点澳大利亚
其他题名膜乳化内部凝胶化技术制备海藻酸钠/壳聚糖微胶囊及其作为药物载体的研究
页码1100/1
ISSN1727-1983/1877040 142
部门归属十八室
主办者International Union for Physical and Engineering Sciences in Medicine (IUPESM), International Federation for Medical and Biological Engineering (IFMBE) ,International Organization for Medical Physics(IOMP)
英文摘要Alginate/chitosan microcapsules prepared by membrane emulsification internal gelation technology and used as drug carriers* X.D. Liu, X.J. Ma**, Q. Yuan Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China. * Granted by National Science Foundation of China (29906011) ** To whom correspondence should be addressed: maxj@dicp.ac.cn Introduction Alginate (anionic polysaccharide) and chitosan (cationic polysaccharide) are popular biomaterials with good biocompatibility. Based on polyelectrolyte complex reaction, alginate-chitosan microcapsules may be prepared under mild conditions. In recent years, there has been increasing interest in the study on using alginate-chitosan microcapsules as delivery carriers of proteins and polypeptides1-2. Being as drug carriers, it has been found that the microcapsule distribution in the body is strongly dependent on their size3 and that the release of drugs is different depending on their size distribution4, therefore it is important to control the size and the size distribution of microcapsules. Methods Firstly, the alginate beads with small size and narrow distribution were prepared by membrane emulsification internal gelation technology5. Secondly, the beads were immersed in hemoglobin (Hb) solution until equilibrium, and then were added into chitosan solution to form alginate/chitosan microcapsules. Finally, the drug loading, encapsulated ratio, and release behaviour of Hb was determined. Results It was shown that the spherical alginate gel beads with mean size range of about 50-100 μm, and with narrow size distribution were successfully obtained using the above technology; the drug loading were above 4.5 mg/(ml beads) with immersion manner, accounting for over 95% of the initial Hb in solution; the encapsulated ratio was under 40%, suggesting that the loss of the water soluble Hb was relatively high during the formation process of the microcapsule membrane; the Hb release from microcapsules in simulated intestinal solution was only 8% after 8h. Conclusion The novel technology established to prepare Ca-alginate beads and alginate-chitosan microcapsules has been proved to overcome the shortcomings of the difficulty for mass production of droplet method and the wide size distribution of emulsification method. The preliminary release experimental has demonstrated the potential of the prepared microcapsules as a sustained carrier for proteins.
语种中文
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/111302
专题中国科学院大连化学物理研究所
通讯作者Ma XJ(马小军)
推荐引用方式
GB/T 7714
Liu XD,Ma XJ,Yuan Q. Alginate/chitosan microcapsules prepared by membrane emulsification internal gelation technology and used as drug carriers[C],2003:1100/1.
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