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学科主题: 物理化学
题名: Mathematical modeling of microbial growth in ACA microcapsules
作者: Qi WT(綦文涛) ;  Yu WT(于炜婷) ;  Jie YB(解玉冰) ;  Ma XJ(马小军)
会议名称: The Eight China-Japan-Korea Joint Symposium on Enzyme Engineering
会议日期: 2004-10-24
出版日期: 2004-10-24
会议地点: 中国
其他题名: ACA微囊化微生物细胞生长过程的数学模拟
通讯作者: 马小军
部门归属: 十八室
主办者: 中国科学院微生物研究所
摘要: Cell microencapsulation is one of the promising biotechnological processes for immobilized cell culture. In this work, E. coli and S. cerevisiae cells were immobilized and cultured in alginate-chitosan-alginate (ACA) microcapsule. The behavior of immobilized and free E. coli and S. cerevisiae cells in culture were studied and simulated by mathematical modeling. The Gompertz function and Richards function were modified and compared to describe the growth and metabolic process of immobilized and free microbial cells in culture for a better understanding of the growth process and its optimization. Both of the modified Gompertz and Richards model could be used to describe the growth and metabolic process in ACA encapsulated culture as well as in non-encapsulated free culture. Particularly, the modified Richards model was more suitable in describing the consumption of the controlling substrate due to the additional parameter, m. The experimental date and the models highlighted that ACA microcapsule immobilized culture could reach a higher maximum biomass concentration and a higher maximum biomass growth rate than in free microbial culture. It is indicated that the ACA microcapsule could be used in immobilized microorganism culture, which offered favorable microenvironment for cell growth. The effects of different status of ACA microcapsule cores on the cell growth and metabolism were further investigated. There was no significant difference in the growth and metabolism of microencapsulated cells whether the cores of the microcapsules were solid or liquefied respectively.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/111570
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Qi WT,Yu WT,Jie YB,et al. Mathematical modeling of microbial growth in ACA microcapsules[C]. 见:The Eight China-Japan-Korea Joint Symposium on Enzyme Engineering. 中国. 2004-10-24.
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