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学科主题: 物理化学
题名: Inhibition of the intestinal bacterial metabolites of ginsenosides on human cytochrome P450 3A4
作者: Liu Y(刘勇) ;  Zhang JW(张江伟) ;  Wang YH(王永华) ;  Yang SL(杨胜利) ;  Deng MC(邓麦村) ;  Yang L(杨凌)
会议名称: the 2 international Science and Technology Conference of Traditional Chinese Medicine Modernization
会议日期: 2005-9-24
出版日期: 2005-09-24
会议地点: 中国
其他题名: 人参皂苷肠道菌代谢物对人细胞色素P450 3A4的抑制
通讯作者: 杨凌
ISSN: 7-5364-5832-0
部门归属: 十八室
摘要: Abstract: The influence of ginsenosides and their intestinal bacterial metabolites (IBMs) on human cytochrome p450 3A4 (CYP3A4) was assayed. We found that Rb1, Rb2, Rc, Rg3, Re, Rg1 and one of IBMs, C-K, had no inhibitory effect, whereas Rd, S-Rg3, Rh2, Rg2, Rh1, F1 exhibit weakly inhibitory activity against CYP3A4 activity, and Ppd and Ppt also exhibit potent inhibition of an enzyme-kinetically competitive type against CYP3A4 activity, with Ki of 2.7±0.5 μM and 3.2±0.4 μM, respectively. The results suggest that the difference of intestinal bacteria in gastrointestinal tract might result in the different influence of food or drugs on hepatic metabolism, which might result in individual-specific drug-drug interactions.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/111862
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Liu Y,Zhang JW,Wang YH,et al. Inhibition of the intestinal bacterial metabolites of ginsenosides on human cytochrome P450 3A4[C]. 见:the 2 international Science and Technology Conference of Traditional Chinese Medicine Modernization. 中国. 2005-9-24.
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