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学科主题: 物理化学
题名: Study of the Association between the Functional SNPs of MDR1 Gene and its Pharmacogenetics
作者: Li YH(李艳红) ;  Hao DC(郝大程) ;  Sun J(孙杰) ;  Wang YH(王永华) ;  Li Y(李燕) ;  Yang SL(杨胜利) ;  Yang L(杨凌)
会议名称: 2005 Hangzhou International Conference on Drug Metabolism
会议日期: 2005-10-17
出版日期: 2005-10-17
会议地点: 中国
通讯作者: 杨凌
部门归属: 十八室
摘要: Abstract: In vivo and in vitro studies have demonstrated that P-glycoprotein (P-gp) plays a very significant role in the processes of ADME (Absorption, Distribution, Metabolism, Excretion) of drugs in human body. P-gp is the product of the multidrug resistance gene MDR1. Pharmacogenomics and pharmacogenetics studies revealed that the genetic polymorphisms of MDR1 have been associated with alterations in expression and function of P-gp in different ethnic subjects. Subsequently, it has been reported that some SNPs (Single Nucleotide Polymorphisms) that have been identified to be risk factors for numerous diseases. In this report, we used three methods (PCR-RFLP, TaqMan probe and DNA sequencing) to identify the functional SNP sites (C3435T, G2677T/A, and T-129C), i.e., 1. allele genotypes; 2. linkage disequilibrium; 3. ethnic difference analysis. We have found that there were no distinct differences among Chinese Han population and other ethnic populations such as European and Asian, but not African. Therefore, it is believed that further investigation of the MDR1 genetic variations may be important for understanding the physiology and biochemistry of P-gp and individualizing pharmacotherapy.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/111882
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Li YH,Hao DC,Sun J,et al. Study of the Association between the Functional SNPs of MDR1 Gene and its Pharmacogenetics[C]. 见:2005 Hangzhou International Conference on Drug Metabolism. 中国. 2005-10-17.
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