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学科主题: 物理化学
题名: Impact of the intestinal metabolites of ginsenosides on human cytochrome P450 enzymes
作者: Liu Y(刘勇) ;  Zhang JW(张江伟) ;  Wang YH(王永华) ;  Deng MC(邓麦村) ;  Yang L(杨凌)
会议名称: 2005 Hangzhou International Conference on Drug Metabolism
会议日期: 2005-10-17
出版日期: 2005-10-17
会议地点: 中国
通讯作者: 杨凌
部门归属: 十八室
摘要: The intestinal metabolites of ginsenosides rather than naturally occurring ginsenosides are really responsible for the main pharmacological activities of ginseng, but the knowledge concerning the effect of those on human metabolism enzymes is still lacking. We found that the intestinal metabolites of ginsenosides demonstrate a wide range of inhibition of CYP-mediated metabolism and in some cases exhibit activation rather than inhibition. It is noteworthy that compound K (C-K), protopanaxadiol (Ppd), and protopanaxatriol (Ppt) all exhibit intermediately inhibitory activity against CYP2C9 activity, and Ppd and Ppt also exhibit potent inhibition of an enzyme-kinetically competitive type against CYP3A4 activity. Further study showed that the inhibition on CYPs is not due to mechanism-based. The results suggest that the ginseng-derived products might influence CYPs activity via their intestinal metabolites, which might be a noteworthy new pathway resulting in clinically significant drug-drug interactions.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/111886
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Liu Y,Zhang JW,Wang YH,et al. Impact of the intestinal metabolites of ginsenosides on human cytochrome P450 enzymes[C]. 见:2005 Hangzhou International Conference on Drug Metabolism. 中国. 2005-10-17.
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