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学科主题: 物理化学
题名: Metabolic Control Analysis of the Catalytic Cycle for Cytochrome P450
作者: Wang YH(王永华) ;  Li Y(李燕) ;  Yang SL(杨胜利) ;  Yang L(杨凌)
会议名称: 2005 Hangzhou International Conference on Drug Metabolism
会议日期: 2005-10-17
出版日期: 2005-10-17
会议地点: 中国
通讯作者: 杨凌
部门归属: 十八室
摘要: Abstract Cytochrome P450 (CYP450) superfamily are versatile catalysts that play a pivotal role in the metabolism of a wide variety of xenobiotic and endogenous compounds. Of major importance is the involvement of these enzymes in drug metabolism and toxicant biotransformation. The variety of oxidative metabolism that P450s catalyzing using a general mechanism is of interest. The catalytic cycle for P450 oxidation is very complex, probably involving more than ten steps. In this paper, metabolic control theory was used to analyze the complex oxidation process. Metabolic control analysis is a powerful quantitative framework for understanding the relationship between the steady-state properties of a (bio)chemical reaction network as a whole and the properties of its component reactions. This paper attempts to capture in P450 catalytic cycle the detailed derivation from first principles of all of the important theorems of control analysis starting with the kinetic model of P450 catalytic cycle of oxidation. In this work, we have calculated control coefficients, 1st and 2nd order response coefficients, spectral response coefficients and the time response coefficients.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/111894
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Wang YH,Li Y,Yang SL,et al. Metabolic Control Analysis of the Catalytic Cycle for Cytochrome P450[C]. 见:2005 Hangzhou International Conference on Drug Metabolism. 中国. 2005-10-17.
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