中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 会议论文
学科主题: 物理化学
题名: Lability of Traditional Chinese Medicine by Intestinal Bacterial Metabolism Results in P450 Cycle-mediated Drug-Drug Interaction
作者: LingYang ;  YongLiu
会议名称: the 6th international symposium on natural medicine and microflora
会议日期: 2006-8-6
出版日期: 2006-08-06
会议地点: 韩国
通讯作者: 杨凌
部门归属: 十八室
摘要: Increasing attention is being paid on how to assess the potential risk for TCM -prescription drug interactions. As many TCMs are capable of biotransformation by intestinal bacteria in the gastrointestinal tract, attention to biotransformation of TCM in the gastrointestinal tract may lead to discovery of novel active components and active mechanisms. In the present study, we proposed that the biotransformation of TCM in human gastrointestinal tract should be integrated into the early evaluation of drug metabolic properties. Ginsenosides were selected as model chemicals since ginseng products are orally administered. There is still no consensus about the in vivo influence of ginseng on cytochrome P450 isoforms (P450s). The majority of naturally occurring ginsenosides (NOGs) is not capable of reaching liver because the absorption of NOGs from the intestines is very poor. However, the intestinal bacteria metabolites, Rh1 and F1, and Compound K (C-K), protopanaxadiol (Ppd), and protopanaxatriol (Ppt) from NOGs may reach the systemic circulation going through liver after oral administration of ginseng extract. We found that in the in vitro experiments, the NOGs exhibited no inhibition or weak inhibition against human P450s activities. Their degradative products in human gastrointestinal tract demonstrate a wide range of direct inhibition of P450-mediated metabolism. The inhibition is reversible and not mechanism-based one. Integrating the in vivo results of their plasma concentrations, we proposed that NOGs might result in ginsenoside-drug interactions via their intestinal bacteria metabolites (C-K, Ppd and Ppt) by influencing CYPs activities. The indirect drug interactions via biotransformation of intestinal bacteria might be a new pathway that needs to be paid additional attention to.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/112202
Appears in Collections:中国科学院大连化学物理研究所_会议论文

Files in This Item:

There are no files associated with this item.


Recommended Citation:
LingYang,YongLiu. Lability of Traditional Chinese Medicine by Intestinal Bacterial Metabolism Results in P450 Cycle-mediated Drug-Drug Interaction[C]. 见:the 6th international symposium on natural medicine and microflora. 韩国. 2006-8-6.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [LingYang]'s Articles
 [YongLiu]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [LingYang]‘s Articles
 [YongLiu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace