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学科主题: 物理化学
题名: Synthesis and application of a mixed functional silica-based β-cyclodextrin for direct injection analysis of drug in serum by high-performance liquid chromatography
作者: Li FL(李方楼) ;  Jia LW(贾乐文) ;  Xu RJ(许人骥) ;  Xu GW(许国旺)
会议名称: Dalian International Symposia and Exhibition on Chromatography
会议日期: 2007-6-4
出版日期: 2007-06-04
会议地点: 中国
通讯作者: 许国旺
ISSN: 978-7-122-00450-5
部门归属: 十八室
主办者: CAS等
摘要: Despite its high resolution power, sensitivity, precision and practicability, high-performance liquid chromatographic (HPLC) analysis of biological samples like blood, serum, plasma, urine, milk, lymphatic fluids, liquor, faeces or tissue homogenates is restricted by the pretreatment and processing of such highly complex matrices. Often the sample preparation represents the weakest chain segment in an analytical HPLC procedure as it still involves many elaborate, manual and thus error-prone and time consuming work-up steps. To solve these problems, direct injection supports and on-line chromatographic techniques have been developed in HPLC. The mixed functional silica having β-cyclodextrin and diol is an important kind of direct injection supports. In this paper, a mixed functional silica-based β-cyclodextrin was synthesized by three steps: synthesis of a 3-glycidoxypropyl silica, introduction of a β-cyclodextrin bonded phase, hydrolysis of the oxirane ring to a diol phase. And then materials were packed into a small stainless-steel column under high pressure as a selective column for direct injection analysis of drugs in serum. Finally, phenobarbital in serum was studied by the short column and the method for the direct analysis showed good chromatographic property.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/112552
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Li FL,Jia LW,Xu RJ,et al. Synthesis and application of a mixed functional silica-based β-cyclodextrin for direct injection analysis of drug in serum by high-performance liquid chromatography[C]. 见:Dalian International Symposia and Exhibition on Chromatography. 中国. 2007-6-4.
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