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学科主题: 物理化学
题名: Liquid chromatography tandem mass spectrometry for determination of catecholamines using alumina-based extraction method
作者: Gu Q(顾群) ;  Shi XZ(石先哲) ;  Lu X(路鑫) ;  Xu GW(许国旺)
会议名称: Dalian International Symposia and Exhibition on Chromatography
会议日期: 2007-6-4
出版日期: 2007-06-04
会议地点: 中国
通讯作者: 许国旺
ISSN: 978-7-122-00450-5
部门归属: 十八室
主办者: CAS等
摘要: Catecholamines including epinephrine, norepinephrine and dopamine are important neurotransmitters in human species. The levels of catecholamines in biologic sample are utilized to diagnose hypertension, pheochromocytoma and neuroblastoma. Different analytical methods are used for catecholamines, such as high-performance liquid chromatography, capillary electrophoresis, mass spectrometric detection, electrochemical detection, chemiluminescence detection and fluorescence detection. Extraction is needed because of low level and interference in the biologic samples. In this work, a method of liquid chromatography tandem mass spectrometry using multiple reaction monitoring (MRM) in the positive ion mode was developed to analyze catecholamines. Multiple reaction monitoring detection not only improved the sensitivity but also selectivity of the determination. In order to isolate the target compounds from the matrix solutes, an alumina-based extraction method was achieved. Different pH values which influenced the adsorbability of alumina were investigated. The precision and the recovery of this method were satisfactory.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/112554
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Gu Q,Shi XZ,Lu X,et al. Liquid chromatography tandem mass spectrometry for determination of catecholamines using alumina-based extraction method[C]. 见:Dalian International Symposia and Exhibition on Chromatography. 中国. 2007-6-4.
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