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学科主题物理化学
Liquid chromatography tandem mass spectrometry for determination of catecholamines using alumina-based extraction method
Gu Q(顾群); Shi XZ(石先哲); Lu X(路鑫); Xu GW(许国旺)
会议名称Dalian International Symposia and Exhibition on Chromatography
会议日期2007-6-4
2007-06-04
会议地点中国
页码254/1
ISSN978-7-122-00450-5
部门归属十八室
主办者CAS等
英文摘要Catecholamines including epinephrine, norepinephrine and dopamine are important neurotransmitters in human species. The levels of catecholamines in biologic sample are utilized to diagnose hypertension, pheochromocytoma and neuroblastoma. Different analytical methods are used for catecholamines, such as high-performance liquid chromatography, capillary electrophoresis, mass spectrometric detection, electrochemical detection, chemiluminescence detection and fluorescence detection. Extraction is needed because of low level and interference in the biologic samples. In this work, a method of liquid chromatography tandem mass spectrometry using multiple reaction monitoring (MRM) in the positive ion mode was developed to analyze catecholamines. Multiple reaction monitoring detection not only improved the sensitivity but also selectivity of the determination. In order to isolate the target compounds from the matrix solutes, an alumina-based extraction method was achieved. Different pH values which influenced the adsorbability of alumina were investigated. The precision and the recovery of this method were satisfactory.
语种中文
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/112554
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
推荐引用方式
GB/T 7714
Gu Q,Shi XZ,Lu X,et al. Liquid chromatography tandem mass spectrometry for determination of catecholamines using alumina-based extraction method[C],2007:254/1.
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