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学科主题: 物理化学
题名: High performance liquid chromatography- mass spectrometry for phospholipid metabonomics: potiental biomarks in chronic glomerulonephritis
作者: Jia LW(贾乐文) ;  Zhao SM(赵素敏) ;  Li FL(李方楼) ;  Xu GW(许国旺)
会议名称: Dalian International Symposia and Exhibition on Chromatography
会议日期: 2007-6-4
出版日期: 2007-06-04
会议地点: 中国
通讯作者: 许国旺
ISSN: 978-7-122-00450-5
部门归属: 十八室
主办者: CAS等
摘要: Plasma phospholipids metabolic profile of chronic glomerulonephritis was investigated. Nineteen phospholipid species were evaluated as potential biomarkers for chronic glomerulonephritis. High performance liquid chromatography/ mass spectrometry and principal components analysis has been used to analyze plasma phospholipids in 18 patients with chronic nephritis, 17 patients with chronic renal failure (CRF) without renal replacement therapy and 18 healthy persons. Primary chronic glomerulonephritis and CRF had phospholipids metabolic abnormality. Nineteen phospholipid species (m/z 833, 857, 861, 863, 883, 885, 887, 909, 911, 913 and 786, 788, 790, 808, 810, 832, 834, 836, 838 in the negative-ion mode) were identified as possible biomarkers in chronic glomerulonephritis and chronic renal failure. More, the recognition of potential phospholipids molecular marker’s structure was obtained by ESI-MS/MS experiment. There was a relationship between plasma phospholipids and level of serum creatinine in chronic kidney disease. In this paper, combination of LC/MS technique with PCA can be successfully applied to phospholipid profile analysis. The result indicated that phospholipids could be useful as potential biomarkers on the progress of primary chronic glomerulonephritis.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/112562
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Jia LW,Zhao SM,Li FL,et al. High performance liquid chromatography- mass spectrometry for phospholipid metabonomics: potiental biomarks in chronic glomerulonephritis[C]. 见:Dalian International Symposia and Exhibition on Chromatography. 中国. 2007-6-4.
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