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学科主题物理化学
High performance liquid chromatography- mass spectrometry for phospholipid metabonomics: potiental biomarks in chronic glomerulonephritis
Jia LW(贾乐文); Zhao SM(赵素敏); Li FL(李方楼); Xu GW(许国旺)
会议名称Dalian International Symposia and Exhibition on Chromatography
会议日期2007-6-4
2007-06-04
会议地点中国
页码259/2
ISSN978-7-122-00450-5
部门归属十八室
主办者CAS等
英文摘要Plasma phospholipids metabolic profile of chronic glomerulonephritis was investigated. Nineteen phospholipid species were evaluated as potential biomarkers for chronic glomerulonephritis. High performance liquid chromatography/ mass spectrometry and principal components analysis has been used to analyze plasma phospholipids in 18 patients with chronic nephritis, 17 patients with chronic renal failure (CRF) without renal replacement therapy and 18 healthy persons. Primary chronic glomerulonephritis and CRF had phospholipids metabolic abnormality. Nineteen phospholipid species (m/z 833, 857, 861, 863, 883, 885, 887, 909, 911, 913 and 786, 788, 790, 808, 810, 832, 834, 836, 838 in the negative-ion mode) were identified as possible biomarkers in chronic glomerulonephritis and chronic renal failure. More, the recognition of potential phospholipids molecular marker’s structure was obtained by ESI-MS/MS experiment. There was a relationship between plasma phospholipids and level of serum creatinine in chronic kidney disease. In this paper, combination of LC/MS technique with PCA can be successfully applied to phospholipid profile analysis. The result indicated that phospholipids could be useful as potential biomarkers on the progress of primary chronic glomerulonephritis.
语种中文
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/112562
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
推荐引用方式
GB/T 7714
Jia LW,Zhao SM,Li FL,et al. High performance liquid chromatography- mass spectrometry for phospholipid metabonomics: potiental biomarks in chronic glomerulonephritis[C],2007:259/2.
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