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学科主题: 物理化学
题名: Metabonomics analysis of Bacteria-infected diarrhea patients based on LC/MS-IT-TOF
作者: Zhang FX(张凤霞) ;  Gao P(高鹏) ;  Li FM(李发美) ;  Xu GW(许国旺)
会议名称: Dalian International Symposia and Exhibition on Chromatography
会议日期: 2007-6-4
出版日期: 2007-06-04
会议地点: 中国
通讯作者: 许国旺
ISSN: 978-7-122-00450-5
部门归属: 十八室
主办者: CAS等
摘要: The core of metabonomic is to study the response of organism under extraneous or endogenic stimuli, which takes place in metabolism level. The objects of metabonomic study are the small molecules ( metabolites ). It is widely used in disease diagnosis and the discovery of biomarkers, also obtains the widespread applications in the drug research and development domains. This work took the diarrhea patient''s fecal samples, after treated with organic solvent, as the objects of the study. Fast HPLC/ IT-TOF MS was used to perform the analysis; simultaneously the data was processed by metabonomics software of Phenomenome Profiler M Series. The potential aims were not only to realize the fast distinguishing between the infectious diarrhea patients and the non-infectious diarrhea patients, but also to pursuit the efficient differentiation of different pathogenic origins. Potential biomarkers which are used in differentiating were identified by using the MSn function of LC/MS-IT-TOF.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/112566
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Zhang FX,Gao P,Li FM,et al. Metabonomics analysis of Bacteria-infected diarrhea patients based on LC/MS-IT-TOF[C]. 见:Dalian International Symposia and Exhibition on Chromatography. 中国. 2007-6-4.
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