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学科主题物理化学
Metabonomics analysis of Bacteria-infected diarrhea patients based on LC/MS-IT-TOF
Zhang FX(张凤霞); Gao P(高鹏); Li FM(李发美); Xu GW(许国旺)
会议名称Dalian International Symposia and Exhibition on Chromatography
会议日期2007-6-4
2007-06-04
会议地点中国
页码263/1
ISSN978-7-122-00450-5
部门归属十八室
主办者CAS等
英文摘要The core of metabonomic is to study the response of organism under extraneous or endogenic stimuli, which takes place in metabolism level. The objects of metabonomic study are the small molecules ( metabolites ). It is widely used in disease diagnosis and the discovery of biomarkers, also obtains the widespread applications in the drug research and development domains. This work took the diarrhea patient''s fecal samples, after treated with organic solvent, as the objects of the study. Fast HPLC/ IT-TOF MS was used to perform the analysis; simultaneously the data was processed by metabonomics software of Phenomenome Profiler M Series. The potential aims were not only to realize the fast distinguishing between the infectious diarrhea patients and the non-infectious diarrhea patients, but also to pursuit the efficient differentiation of different pathogenic origins. Potential biomarkers which are used in differentiating were identified by using the MSn function of LC/MS-IT-TOF.
语种中文
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/112566
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
推荐引用方式
GB/T 7714
Zhang FX,Gao P,Li FM,et al. Metabonomics analysis of Bacteria-infected diarrhea patients based on LC/MS-IT-TOF[C],2007:263/1.
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