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学科主题物理化学
Degree of deacetylation effects on biodegradation of chitosan-alginate polyelectrolyte complexes
Li XX(李晓霞); Xie HG(谢红国); Ma XJ(马小军); Xiaojun MA
会议名称2 nd Asian Symposium on Emulsion Polymerization and Functional Polymeric Microspheres
会议日期2007-9-9
2007-09-09
会议地点中国
其他题名脱乙酰度对壳聚糖-海藻酸钠聚电解质复合物降解的影响
页码45/1
部门归属十八室
主办者中科院过程工程研究所
英文摘要Microcapsules made of polyelectrolyte complexes(PECs) have shown potential in the area of cell transplantation, enzyme immobilization and drug delivery system. PECs are formed when oppositely charged polyelectrolytes are mixed and interact via electrostatic interactions. Chitosan, which is a copolymer derived from natural polymer chitin and composed of N-acetyl-D-glucosamine and D-glucosamine and alginate, which is a polysaccharide derived from brown seaweed and comprises blocks of β-D-guluronic and α-L-mannuronic, can be used to form PECs, and then obtain chitosan-alginate complex microcapsules. . The successful application of microcapsules requires an understanding of the biodegradation of materials. Since chitosan is degraded by enzymatic systems in vivo, depending on the degree of deacetylation (DD), it was hypothesized that chitosan-alginate complexes could also be biodegraded. Therefore, the current study focused on PECs of sodium alginate and chitosans with DD of 93%, 81%, 72% and 61%, evaluating their structures by FTIR and XRD and biodegradation behaviors in vitro with lysozyme system. The degradation studies were performed at 37 oC and 120 rpm. The degradation kinetics was assessed by evaluating the lysozyme and cumulative degradation products in solution with Bradford method and potassium ferricyanide method. Meanwhile, the weight-loss of PECs was monitored during the whole degradation process and the morphological structure was observed by SEM. Lysozyme in the solution was adsorbed onto the complexes on the first day, and the lower the DD was, the more lysozyme was adsorbed. Meanwhile, the degradation started and reducing sugars were produced, and the lower the DD was, the more reducing sugars released. After 8 weeks of degradation, PEC from DD61% had the most loss-weight and reducing sugars, but PEC from DD91% was nearly degraded. SEM image also showed that there became fibrillar structures in PEC from DD61%, but PEC from DD93% retained the primary structure. Our results revealed that biodegradation of chitosan-alginate PECs are highly dependent on DD of chitosans, though the result of the FTIR and XRD indicated that DD had little influence on the structure of PECs. It is suggest a better control of the degradation kinetics when chitosan-alginate microcapsules are used in biomedical engineering.
语种中文
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/112752
专题中国科学院大连化学物理研究所
通讯作者Xiaojun MA
推荐引用方式
GB/T 7714
Li XX,Xie HG,Ma XJ,et al. Degree of deacetylation effects on biodegradation of chitosan-alginate polyelectrolyte complexes[C],2007:45/1.
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