DICP OpenIR
Subject Area物理化学
Magnetically separable biocatalyst for efficient resolution of racemic secondary alcohols
Zhang YM(张艳梅); Li J(李军); Han DF(韩涤非); Liu P(刘鹏); Gao Q(高强); Li C(李灿)
Conference Name14th International Congress on Catalysis
Conference Date2008-7-13
2008-07-13
Conference Place韩国
Alternative Title可磁性分离的高效拆分手性醇的生物催化剂
Pages185/1
Department五室
Funding Organization第十四届国际催化会议组委会
AbstractThe combination of magnetic nanoparticles and mesoporous silica can present a strategy for enzyme immobilization. In this paper, we present the preparation of a magnetically separable, highly efficient biocatalyst adsorbed in magnetic siliceous mesocellular foam for the kinetic resolution of racemic secondary alcohols. The resolution of 1-phenylethanol acylated with vinyl acetate can be achieved within 1.5 h using the resultant magnetic biocatalyst, whereas only a conversion of 30% was obtained by using the free lipase under the identical reaction conditions. Moreover, the biocatalyst entrapped in the nanopores of the foam can be recycled magnetically for at least seven times without significant loss of its activity and enantioselectivity. This approach could be a general strategy for the immobilization of various enzymes and for a wide application in catalysis as well as other fields.
Language中文
Document Type会议论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/112914
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi C(李灿)
Recommended Citation
GB/T 7714
Zhang YM,Li J,Han DF,et al. Magnetically separable biocatalyst for efficient resolution of racemic secondary alcohols[C],2008:185/1.
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