Subject Area物理化学
Epoxidation of cyclohexene in t-butyl alcohol/water mixtures catalyzed by vanadium bromoperoxidase from Corallina officinalis
Zhang BM(章表明); Wu PC(吴佩春); Zhang W(张卫)
Conference Name13th International Biotechnology Symposium and Exhibition
Conference Date2008-10-12
Conference Place中国
Funding Organization中国科学院,中国工程院,中国教育部,中国科技部,中国国家发改委
AbstractCurrent interests in catalytic oxidative transformations in chemical industry are to replace oxidation catalysts that consist of heavy metals, and to develop catalysts with high chemo-, regio- or enantioselectivities (Valery, 2003). Haloperoxidases are potentially suitable biocatalysts to meet these goals (Valery, 2003). In recent years, there is a substantial interest on vanadium bromoperoxidase (VBPO) due to its excellent thermostability, operation stability and broad spectra of substrates such as methyl phenyl ether, 1-methoxylnaphthalenethiophene, indene, organic sulfide, indole terpenes (Valery, 2003; Itoh et al., 1988). In our previous studies we have investigated the epoxidation of cyclohexene to form 1,2- cyclohexane catalyzed by VBPO isolated from the marine red algae Corallina officinalis with a yield of 2.8 g l−1 h−1 and 82% selectivity (Yu et al., 2007). The epoxidationwas performed in awater-organic biphasic solvent system and the solubility of the cyclohexene is too low in water. In this work, t-butyl alcohol was used as a co-solvent in order to enhance the solubility of cyclohexene in water. A final yield of 3.2 g l−1 h−1 of 1,2-cyclohexane with 96% selectivity was achieved. The reaction was completed within 4 h that is shorter than that without co-solvent (6 h). The results indicated that tbutyl alcohol/water (2%, v/v) was an excellent co-solvent system to improve the bio-oxidation efficiency of cyclohexene by VBPO, with further optimization required.
WOS IDWOS:000208979401357
Citation statistics
Document Type会议论文
Corresponding AuthorZhang W(张卫)
Recommended Citation
GB/T 7714
Zhang BM,Wu PC,Zhang W. Epoxidation of cyclohexene in t-butyl alcohol/water mixtures catalyzed by vanadium bromoperoxidase from Corallina officinalis[C],2008:S369/2.
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