Subject Area物理化学
Camptothecin from Camptotheca acuminate hairy roots
Yue XG(岳向国); Zhang W(张卫)
Conference Name13th International Biotechnology Symposium and Exhibition
Conference Date2008-10-12
Conference Place中国
Funding Organization中国科学院,中国工程院,中国教育部,中国科技部,中国国家发改委
AbstractCamptothecin (CPT) is an important anticancer and antiviral alkaloid produced by the Chinese native tree Camptotheca acuminate (Nyssaceae) and other species belonging to the families Apocynaceae, Olacaceae, and Rubiaceae. Attempts have been made to produce CPT from cell suspension cultures; however, low and unstable yield obtained limited the industrial development of this approach. This inability of CPT biosynthesis is thought to relate to the de-differentiation status of suspension cells. It has been proposed that the cultures of hairy roots may be an alternative source of alkaloid production, due to its highly differentiated status.Anefficient transformation systemwas established inCamptotheca acuminate by Agrobacterium rhizogenes strains ATCC A4 and R-1000.The biosynthesis of camptothecin was detected and the integration of the genes responsible for the hairy-root phenotype (rol genes) into the plant genomewas verified by DNA gel blot anal-ysis. Hairy roots could grownormally on solid or liquid MS medium without a growth regulator.
WOS IDWOS:000208979400351
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type会议论文
Corresponding AuthorZhang W(张卫)
Recommended Citation
GB/T 7714
Yue XG,Zhang W. Camptothecin from Camptotheca acuminate hairy roots[C],2008:S155/2.
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