DICP OpenIR
学科主题物理化学
Camptothecin from Camptotheca acuminate hairy roots
Yue XG(岳向国); Zhang W(张卫)
会议名称13th International Biotechnology Symposium and Exhibition
会议日期2008-10-12
2008-10-12
会议地点中国
页码S155/2
部门归属十八室
主办者中国科学院,中国工程院,中国教育部,中国科技部,中国国家发改委
英文摘要Camptothecin (CPT) is an important anticancer and antiviral alkaloid produced by the Chinese native tree Camptotheca acuminate (Nyssaceae) and other species belonging to the families Apocynaceae, Olacaceae, and Rubiaceae. Attempts have been made to produce CPT from cell suspension cultures; however, low and unstable yield obtained limited the industrial development of this approach. This inability of CPT biosynthesis is thought to relate to the de-differentiation status of suspension cells. It has been proposed that the cultures of hairy roots may be an alternative source of alkaloid production, due to its highly differentiated status.Anefficient transformation systemwas established inCamptotheca acuminate by Agrobacterium rhizogenes strains ATCC A4 and R-1000.The biosynthesis of camptothecin was detected and the integration of the genes responsible for the hairy-root phenotype (rol genes) into the plant genomewas verified by DNA gel blot anal-ysis. Hairy roots could grownormally on solid or liquid MS medium without a growth regulator.
语种中文
WOS记录号WOS:000208979400351
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/113128
专题中国科学院大连化学物理研究所
通讯作者Zhang W(张卫)
推荐引用方式
GB/T 7714
Yue XG,Zhang W. Camptothecin from Camptotheca acuminate hairy roots[C],2008:S155/2.
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