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学科主题: 物理化学
题名: Camptothecin from Camptotheca acuminate hairy roots
作者: Yue XG(岳向国) ;  Zhang W(张卫)
会议名称: 13th International Biotechnology Symposium and Exhibition
会议日期: 2008-10-12
出版日期: 2008-10-12
会议地点: 中国
通讯作者: 张卫
部门归属: 十八室
主办者: 中国科学院,中国工程院,中国教育部,中国科技部,中国国家发改委
摘要: Camptothecin (CPT) is an important anticancer and antiviral alkaloid produced by the Chinese native tree Camptotheca acuminate (Nyssaceae) and other species belonging to the families Apocynaceae, Olacaceae, and Rubiaceae. Attempts have been made to produce CPT from cell suspension cultures; however, low and unstable yield obtained limited the industrial development of this approach. This inability of CPT biosynthesis is thought to relate to the de-differentiation status of suspension cells. It has been proposed that the cultures of hairy roots may be an alternative source of alkaloid production, due to its highly differentiated status.Anefficient transformation systemwas established inCamptotheca acuminate by Agrobacterium rhizogenes strains ATCC A4 and R-1000.The biosynthesis of camptothecin was detected and the integration of the genes responsible for the hairy-root phenotype (rol genes) into the plant genomewas verified by DNA gel blot anal-ysis. Hairy roots could grownormally on solid or liquid MS medium without a growth regulator.
语种: 中文
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内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113128
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Yue XG,Zhang W. Camptothecin from Camptotheca acuminate hairy roots[C]. 见:13th International Biotechnology Symposium and Exhibition. 中国. 2008-10-12.
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