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学科主题: 物理化学
题名: Development and comparison of three different methods for the analysis of traditional Chinese medicine
作者: Liu YM(刘艳明) ;  Xue XY(薛兴亚) ;  Xu Q(徐青) ;  Zhang FF(章飞芳) ;  Liang XM(梁鑫淼)
会议名称: 13th International Biotechnology Symposium & Exhibition
会议日期: 2008-10-12
出版日期: 2008-10-12
会议地点: 中国
其他题名: 三种中药分析方法发展与比较
通讯作者: 梁鑫淼
部门归属: 十八室
主办者: 中国科学院、中国工程院、教育部、科技部和国家发改委
摘要: As an important resource for drug development, the traditional Chinese medicine (TCM) is a typical complex matrix. The bioactive ingredients existing in TCM are often in trace amount. Therefore, highly efficient methods are required for the separation and identification of the ingredients in it. In this work, three methods, including liquid chromatography, two-dimensional liquid chromatography (2D-LC) based on the same C18 column but different organic modifiers tetrahydrofuran and acetonitrile in the two dimensions and computer-simulation methods accomplished by Complex Sample Analysis Software System (CSASS)(Jin et al., 2008) were developed for the analysis of the chloroform extract of swertia franchetiana Smith, which is a traditional Tibetan medicine for treatment of hepatitis and cholecystitis. Through comparison of the three methods, it can be concluded that the uni-dimensional chromatography was simplest among the three ones. It has least requirement on instrument, operation and data processing. But the information obtained was the least, too. Computer-aided optimization methods may be the compromise among the three methods. Much information may be obtained by computer without interminable experiments. But the defects of it lay in its low ability for the discovery of low-abundant components, and much information about the sample may be lost. More peaks can be detected by the 2DLC method, although its operation was most complicated among the three ones. The results of the three methods can be combined and approved by each other. The pattern of the simulated chromatogram was in accord with that of one-dimensional separation under the same chromatographic condition, which validated the correctness of the prediction of the CSASS software to some degrees. It was predicted by the CSASS software that some peaks cannot be separated under any conditions in the given one-dimensional column system. The result of 2DLC separation could justify the existence of these compounds as they were well resolved.
语种: 中文
Citation statistics: 
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113150
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Liu YM,Xue XY,Xu Q,et al. Development and comparison of three different methods for the analysis of traditional Chinese medicine[C]. 见:13th International Biotechnology Symposium & Exhibition. 中国. 2008-10-12.
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