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学科主题物理化学
A new chemically bonded β-CD silica based stationary phases for the separation of anthraquinones from Rrheum palmatum L.
Zhao YY(赵艳艳); Zhang YP(张永平); Guo ZM(郭志谋); Xue XY(薛兴亚); Liang XM(梁鑫淼)
会议名称13th International Biotechnology Symposium & Exhibition
会议日期2008-10-12
2008-10-12
会议地点中国
其他题名一种新型化学键合β环糊精硅胶固定相用于大黄中蒽醌化合物的分离
页码S755/2
部门归属十八室
主办者中国科学院、中国工程院、教育部、科技部和国家发改委
英文摘要Rheum palmatum L. is a kind of traditional Chinese medicine which is famous for its application on intestinal disease. A novel chemically bonded urea linked peracetyl-β-CD silica based stationary phases was synthesized and a chromatographic method in reversed-phase liquid chromatography mode was established to separate anthraquinones from Rheum palmatum L. The novel β-CD stationary phase was synthesized according to the method of click chemistry and was packed into a stainless-steel column (150 mm × 4.6 mm I.D.) [1]. A fraction of Rheum palmatum L. extraction which was eluted with 60% alcohol aqueous on the non polar porous resin was selected as study object. The pharmaceutically relevant compounds in Rheum palmatum L. are anthraquinone derivatives, a significant character of the anthraquinones is the absorption under 400 nm caused by carbonyl group [2]. Thus, after optimizing the chromatographic condition, we compared the same chromatography spectrums under 400 nm and 300 nm and comparison was carried out between C18 and β-CD phases. From the primary result we found that the anthraquinones were mostly eluted between 14 minute and 24 minute, other compounds were almost eluted before 10 minute. However, anthraquinones were co-eluted with other compounds on C18 phase. The result indicated that the novel β-CD phase had good selectivity and clustering effect in the separation of the anthraquinones from Rheum palmatum L. References [1] Guo Z. M., Lei A. W., Liang X. M. , Xu Q., 2006. Click chemistry: a new facile and efficient strategy for preparation of functionalized HPLC packings. Chem. Comumn. 43, 4512-4514 [2] Yao X.S., 2004, phytochemistry. Peolple’s Medical Publishing House, 160
语种中文
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/113158
专题中国科学院大连化学物理研究所
通讯作者Liang XM(梁鑫淼)
推荐引用方式
GB/T 7714
Zhao YY,Zhang YP,Guo ZM,et al. A new chemically bonded β-CD silica based stationary phases for the separation of anthraquinones from Rrheum palmatum L.[C],2008:S755/2.
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