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学科主题: 物理化学
题名: Separation of Chitooligosaccharides (DP2-6) Monomers and the Potent Angiogenic Inhibition Effect of Chitohexaose in vitro
作者: Xiong CN(熊川男) ;  Wei P(魏鹏) ;  Wu HG(吴海歌) ;  IsaoKusakabe ;  Ma XJ(马小军) ;  Du YG(杜昱光)
会议名称: 2008 Annual Meeting of the Society for Glycobiology
会议日期: 2008-11-12
出版日期: 2008-11-12
会议地点: 美国
通讯作者: 杜昱光
部门归属: 十八室
主办者: glycobiology
摘要: Chitooligosaccharides(DP2-7, 95% deacetylated) were separated to five monomers for the first time by a acid-ion-exchange resin with linear gradient of HCl solution from 2.0M to 3.0M, and was followed by a charcoal column to remove HCl from sugar. HPLC and MALDI-TOF mass spectrum were performed to analysis the monomers. Chitobiose was 341Da with retention time of 10.2min. Chitotriose was 502Da with retention time of 9.6min. Chitotetraose was 663Da with retention time of 8.6min. Chitopentaose was 824Da with retention time of 7.3min. Chitohexaose was 985Da with retention time of 6.9min. The molecular masses were exactly without any acetyls. In our previous study, we found the anti-angiogenic activities of COS and in present research, the COS monomers were used to confirm the exact component which had the potent anti-angiogenic activity. The results showed chitohexaose had no toxicity to normal HUVECs, but could inhibit the proliferation and migration of induced HUVECs in a dose-dependant manner.
语种: 中文
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内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113212
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Xiong CN,Wei P,Wu HG,et al. Separation of Chitooligosaccharides (DP2-6) Monomers and the Potent Angiogenic Inhibition Effect of Chitohexaose in vitro[C]. 见:2008 Annual Meeting of the Society for Glycobiology. 美国. 2008-11-12.
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