Subject Area物理化学
Hepatoprotective activity of chitooligosaccharides against
Xu QS(许青松); Dou JL(窦江丽); Bai XF(白雪芳); Du YG(杜昱光)
Conference NameThe 13th International Biotechnology Symposium
Conference Date2008-10-12
Conference Place中国
Funding Organization中国科学院 中国工程院 中华人民共和国教育部 中华人民共和国科学技术部 中华人民共和国国家发展改革委员会
AbstractChitooligosaccharides (COS) is partially hydrolyzed products of chitosan, which has various biological activities including hepatoprotective activity (Santhosh et al., 2007; Shon et al., 2002).The protective effects of COS on ethanol-induced liver damage were investigated in rats. Liver injury model was established by administration of ethanol to rats. The activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the contents of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in hepatic tissues were measured (Yan et al., 2006). Hepatic histological changes were observed by optical microscope. The increases in the activity of serum ALT and the level of liver lipid peroxidation (2.1-fold and 2.6-fold) induced by ethanol were significantly inhibited by oral administration with 100, 200 mg/kg of COS. Morphological observation further confirmed the hepatoprotective effects of COS. In addition, the suppression of antioxidant enzyme (superoxide dismutase) in the liver of ethanol-intoxicated rats was effectively prevented by administration with COS. Further, COS supplementation prevented the ethanol induced cleave of poly (ADP-ribose) polymerase (PARP). It can be concluded the COS had protective effects against liver damage induced by ethanol. Keywords: Chitooligosaccharides; Ethanol; Hepatoprotection
Document Type会议论文
Corresponding AuthorDu YG(杜昱光)
Recommended Citation
GB/T 7714
Xu QS,Dou JL,Bai XF,et al. Hepatoprotective activity of chitooligosaccharides against[C],2008:S581/2.
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