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学科主题: 物理化学
题名: Hepatoprotective activity of chitooligosaccharides against
作者: Xu QS(许青松) ;  Dou JL(窦江丽) ;  Bai XF(白雪芳) ;  Du YG(杜昱光)
会议名称: The 13th International Biotechnology Symposium
会议日期: 2008-10-12
出版日期: 2008-10-12
会议地点: 中国
通讯作者: 杜昱光
部门归属: 十八室
主办者: 中国科学院 中国工程院 中华人民共和国教育部 中华人民共和国科学技术部 中华人民共和国国家发展改革委员会
摘要: Chitooligosaccharides (COS) is partially hydrolyzed products of chitosan, which has various biological activities including hepatoprotective activity (Santhosh et al., 2007; Shon et al., 2002).The protective effects of COS on ethanol-induced liver damage were investigated in rats. Liver injury model was established by administration of ethanol to rats. The activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the contents of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in hepatic tissues were measured (Yan et al., 2006). Hepatic histological changes were observed by optical microscope. The increases in the activity of serum ALT and the level of liver lipid peroxidation (2.1-fold and 2.6-fold) induced by ethanol were significantly inhibited by oral administration with 100, 200 mg/kg of COS. Morphological observation further confirmed the hepatoprotective effects of COS. In addition, the suppression of antioxidant enzyme (superoxide dismutase) in the liver of ethanol-intoxicated rats was effectively prevented by administration with COS. Further, COS supplementation prevented the ethanol induced cleave of poly (ADP-ribose) polymerase (PARP). It can be concluded the COS had protective effects against liver damage induced by ethanol. Keywords: Chitooligosaccharides; Ethanol; Hepatoprotection
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113214
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Xu QS,Dou JL,Bai XF,et al. Hepatoprotective activity of chitooligosaccharides against[C]. 见:The 13th International Biotechnology Symposium. 中国. 2008-10-12.
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