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学科主题: 物理化学
题名: Gene expression of galectins during the apoptosis of HL-60 cells induced by chitosan oligosaccharides
作者: Dou JL(窦江丽) ;  Tan CY(谭成玉) ;  Du YG(杜昱光) ;  Ma XJ(马小军)
会议名称: The 13th International Biotechnology Symposium
会议日期: 2008-10-12
出版日期: 2008-10-12
会议地点: 中国
通讯作者: 杜昱光
部门归属: 十八室
主办者: 中国科学院 中国工程院 中华人民共和国教育部 中华人民共和国科学技术部 中华人民共和国国家发展改革委员会
摘要: Galectins are one of the animal lectins characteristically possessing one or two carbohydrate recognition domains (CRD) of 14 kDa with a high affinity to -galactosides of glycoconjugates. Galectins modulate a variety of biological functions, such as cell activation, proliferation, adhesion, and apoptosis (Hernandez and Baum,2002). To investigate the roles of galectins play during the apoptosis of HL-60 cells induced by chitosan oligosaccharides (COSs), the gene expression was detected by RT-PCR. The pro-apoptotic galectins (Ueda et al., 2004; Irie et al., 2005) were up-regulated by COS after administration for 3, 5 and 7days, like galectin-9 and 10. We supposed that the over expression of these galectin stimulated by COS had positive effects on the apoptosis of HL-60.
语种: 中文
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内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113246
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Dou JL,Tan CY,Du YG,et al. Gene expression of galectins during the apoptosis of HL-60 cells induced by chitosan oligosaccharides[C]. 见:The 13th International Biotechnology Symposium. 中国. 2008-10-12.
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