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学科主题: 物理化学
题名: ALGINATE/CHITOSAN ARTIFICIAL CELL MICROCAPSULES FOR ORAL DELIVERY OF GENETICALLY ENGINEERED BACTERIAL CELLS FOR THERAPY
作者: Lin JZ(林军章) ;  Yu WT(于炜婷) ;  Liu XD(刘袖洞) ;  Zhang Y(张瑛) ;  Wang W(王维) ;  Ma XJ(马小军)
会议名称: 13th International Biotechnology Community
会议日期: 2008-10-12
出版日期: 2008-10-12
会议地点: 中国
其他题名: AC微囊化基因工程微生物口服治疗研究
通讯作者: 马小军
部门归属: 十八室
主办者: 中国科学院,中国工程院,中华人民共和国教育部,中华人民共和国科学技术部,中华人民共和国国家发展改革委员会
摘要: The oral administration of artificial cell microcapsules entrapping the live bacterial cells provides a promising potential for the therapy of diseases [1,2]. The present obtainable microcapsules, however, shows inherent shortcomings and limits the clinical application [3]. In this paper, the alginate/chitosan (AC) microcapsules entrapping genetically engineered E.coli DH5 cells oral delivery for therapy kidney failure was investigated. It is shown that the AC microcapsules keep intact and stable in rat gastrointestinal tract, and the microencapsulated bacterial cells can survive in vivo. This artificial cells encapsulated genetically engineered E.coli DH5 cells also have the ability to lower urea in rat’s blood from 63.3mg/dl to 21.7mg/ml. Therefore, AC microcapsules have a good promising potential for oral delivery of live bacterial cells for therapy.
语种: 中文
Citation statistics: 
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113420
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Lin JZ,Yu WT,Liu XD,et al. ALGINATE/CHITOSAN ARTIFICIAL CELL MICROCAPSULES FOR ORAL DELIVERY OF GENETICALLY ENGINEERED BACTERIAL CELLS FOR THERAPY[C]. 见:13th International Biotechnology Community. 中国. 2008-10-12.
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