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学科主题: 物理化学
题名: Hydrodynamic characteristics of microcapsules in a fluidized bed used for bioartificial liver
作者: Huang XB(黄晓波) ;  Wang JZ(王建政) ;  Zhang Y(张英) ;  Wang W(王为) ;  Ma XJ(马小军)
会议名称: 13th International Biotechnology Symposium and Exhibition
会议日期: 2008-10-12
出版日期: 2008-10-12
会议地点: 中国
其他题名: 微胶囊在用于生物人工肝的流化床反应器内的流体动力学研究
通讯作者: 马小军
ISSN: 0168-1656
部门归属: 十八室
主办者: 中国科学院
摘要: This study examined the hydrodynamic characteristics of APA microcapsules (Alginate-Poly-Lysine-Alginate) in a liquid-solid fluidized bed used for bioartificial liver. A detailed knowledge of hydrodynamic behavior of microcapsules is the first essential step for the correct design and operation of the fluidized bed[1,2]. The hydrodynamic properties include particle densities, terminal settling velocities, drag coefficient, and minimum fluidization velocities for immobilized cell beads of various particle sizes[3,4]. From experimental measurements of the single particle terminal settling velocity, the corresponding drag coefficient was found to be larger than that of a smooth, rigid sphere whereas to be in agreement with that of a elastic sphere. In addition, the drag coefficient-Reynolds number, velocity-voidage, and expansion index-Reynolds number relationships observed in our experiments were compared with the published results. Our experimental findings were inconsistent with the predictions made from previous correlations because of the difference of particles in physical characteristics[5-7]. Thus, new correlations describing the above-mentioned relationships were suggested. For multiparticle systems, the correction factor, f(ε), is a function of Reynolds number as well as Archimedes, and depends strongly on the bed voidage(ε). A new simple relation was developed to predict easiliy the voidage value from 0.45 to 0.90 at 945< Ar <13753. Furthmore, all the data were calculated by the means of the proposed equation and compared to the experimental measurements. A satisfactory accordance between experimental and calculated curves was observed.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113426
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Huang XB,Wang JZ,Zhang Y,et al. Hydrodynamic characteristics of microcapsules in a fluidized bed used for bioartificial liver[C]. 见:13th International Biotechnology Symposium and Exhibition. 中国. 2008-10-12.
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