Subject Area物理化学
Protein Equalizer Based on scFv Displaying M13 Phage Library for Serum Proteome Analysis
Zhao P(赵鹏); Zhang LH(张丽华); Liang Z(梁振); Zhang YK(张玉奎)
Conference NameHUPO 8th Annual World Congress
Conference Date2009-9-26
Conference Place加拿大
Funding OrganizationYork University
AbstractThe decrease of proteome complexity by removing high abundance proteins is essential to discover low abundance ones with important biological functions. Although antibody columns are proven effective to deplete several kinds of high abundance proteins (1), it is impossible to remove unknown high abundance proteins. Righetti proposed the technique of protein equalizer by immobilizing combinatorial peptide ligands on silica, by which proteins were bound to beads according to the specific interaction with ligands instead of the amount (2). In our recent work, a novel protein equalizer based on scFv displaying M13 phage library was developed with monolithic cryogel as the matrix, by which the identified protein number from human serum was nearly increased by a factor of 1.85.
Document Type会议论文
Corresponding AuthorZhang LH(张丽华)
Recommended Citation
GB/T 7714
Zhao P,Zhang LH,Liang Z,et al. Protein Equalizer Based on scFv Displaying M13 Phage Library for Serum Proteome Analysis[C],2009:126/1.
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