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学科主题: 物理化学
题名: INHIBITION OF CURCUMENOL TO HUMAN LIVER CYTOCHROME P450 ENZYMES
作者: Sun DX(孙冬雪) ;  Fang ZZ(房中则) ;  Zhang YY(张延延) ;  Yang L(杨凌)
会议名称: International Society for the Study of Xenobiotics
会议日期: 2009-10-18
出版日期: 2009-10-18
会议地点: 美国
通讯作者: Ling Yang
部门归属: 十八室
主办者: AllChemie Inc.
摘要: Abstract: Curcumenol, one of the major components of Zedoary Turmeric Oil, has been widely used to treat cancer and inflammation. In Chinese Pharmacopoeia, curcumenol is also recognized as a phytochemical marker for the quality control of Zedoary Turmeric Oil. As antibiotics or anticancer drug, curcumenol is highly likely to be used in combination with various synthetic drugs in most cases, thus it is necessary to evaluate potential pharmacokinetic drug-drug interactions induced by curcumenol. In this article the inhibition of curcumenol to seven CYP isoforms was investigated and the results demonstrated that only CYP3A4 was strongly inhibited (IC50=15.6±0.1 μM). Kinetic analyses showed the inhibition type was competitive with Ki value of 11.6 μM. Time- and NADPH-dependent inhibitions were also investigated to show curcumenol is not a mechanism-based inhibitor. Employing these in vitro data and dog’s in vivo pharmacokinetic data, [I]/Ki was predicted to be 0.00156 which suggested that curcumenol as antibiotics and antitumor agent may be safely used without inducing drug-drug interaction. Nevertheless, due to the limited pharmacokinetic data of Curcumenol in humans, it is nigh impossible to evaculate its potential effects to human from in vitro data. Further work will be done in the future.
语种: 中文
Citation statistics: 
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113670
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Sun DX,Fang ZZ,Zhang YY,et al. INHIBITION OF CURCUMENOL TO HUMAN LIVER CYTOCHROME P450 ENZYMES[C]. 见:International Society for the Study of Xenobiotics. 美国. 2009-10-18.
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