Subject Area物理化学
Dithioacetalization in Water by DNA Catalysis
Wang ZH(王长号); Zhou J(周俊); Jia GQ(贾国卿); Chang T(常涛); Liu P(刘鹏); Li C(李灿)
Conference Name第十三届亚洲化学会物理化学分会
Conference Date2009-9-13
Conference PlaceChina
Funding OrganizationChinese Chemical Society
AbstractDithioacetals are very useful in organic synthesis as powerful protective groups for carbonyl compounds, which are commonly obtained in acid-catalyzed reactions.[1] Herein, we have presented a new approach to dithioacetals by DNA-based catalysis, which gives rise to high yield of dithioacetalization in water (Scheme 1). Carbonyl compounds i.e. cyclohexanone and benzaldehyde are almost totally transformed to dithioacetals under mild conditions. Furthermore, we have observed a series of interesting phenomena: e.g. the reaction catalyzed by hsDNA performs better than that by HCl at the same pH value, which can be ascribed to the special properties of double helix of DNA and adjustment of the media by phosphate and bases (Figure 1). This approach will not only provide a new aspect of organic reaction in DNA catalysis but also may be helpful in learning the role of DNA as a catalyst during the development of life.
Document Type会议论文
Corresponding AuthorLi C(李灿)
Recommended Citation
GB/T 7714
Wang ZH,Zhou J,Jia GQ,et al. Dithioacetalization in Water by DNA Catalysis[C],2009:41/1.
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