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学科主题: 物理化学
题名: Chromatographic Methodology and Technology for Developing Multi-Component Chinese Medicine
作者: Liang XM(梁鑫淼) ;  Zhang XL(张秀莉) ;  Xue XY(薛兴亚) ;  Feng JT(丰加涛)
会议名称: The 13th Beijing Conference and Exhibition on Instrumental Analysis
会议日期: 2009-11-25
出版日期: 2009-11-25
会议地点: 中国
其他题名: 组分中药色谱分离方法学研究
通讯作者: 梁鑫淼
部门归属: 十八室
主办者: 中国分析测试协会
摘要: Presently, Traditional Chinese Medicine (TCM) is an important resource to treat many diseases, which has a long history in China, and is very complicated in chemical composition and pharmacology. Therefore, modernization of TCM is very necessary, including standardization, resourcing, quality control and research on chemical composition and pharmacology. “Multi-Component Chinese Medicine (MCCM)” represents a specific group of chemical composition produced from TCM according to a standardized separation process, which is hopefully to discover the chemical fundament of TCM’s pharmacology. The systematic research on MCCM is basing on modern separation and analytical techniques. In our group, a high-throughput preparation method has been developed in order to accelerate the pharmacological study of MCCM. The whole of TCMs were separated into a serious of small fractions containing several compounds by high-throughput preparative chromatography. Then these small fractions, what is called screening multi-components (SMCs), were screened by high-throughput screening (HTS). After biological screening, active multi-components were obtained and could be studied deeply further. This method will accelerate the process of explanation of the curative mechanism of TCMs, which simplifies the complex TCMs by concentrating on those interesting compounds from hundreds of thousands of compounds in TCMs. Standard libraries of SMCs are constructed, which will not only satisfy the need of TCMs, but also will speed up drug discovery by supplying persistent source for HTS. Two-dimensional liquid chromatography (2DLC) systems have developed for the characterization of SMCs and preparation of active compounds. Orthogonality and compatibility between the two-dimensional separations are key factors affecting the development of 2DLC. Based on the development of novel stationary phases, RP-HILIC 2DLC system and RP-RP 2DLC system were established.Two-dimensional liquid chromatography (2DLC) systems have developed for the characterization of SMCs and preparation of active compounds. Orthogonality and compatibility between the two-dimensional separations are key factors affecting the development of 2DLC. Based on the development of novel stationary phases, RP-HILIC 2DLC system and RP-RP 2DLC system were established.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113872
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Liang XM,Zhang XL,Xue XY,et al. Chromatographic Methodology and Technology for Developing Multi-Component Chinese Medicine[C]. 见:The 13th Beijing Conference and Exhibition on Instrumental Analysis. 中国. 2009-11-25.
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