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学科主题: 物理化学
题名: Lysophosphatidylcholines profiling of plasma: isomers discrimination and biomarkers discovery in lung cancer
作者: Dong J(董军) ;  Zhang XL(张秀莉) ;  Cai XM(蔡晓明) ;  Zou LJ(邹丽娟) ;  Xue XY(薛兴亚) ;  Liang XM(梁鑫淼)
会议名称: 24th International Symposium on Microscale Bioseparations
会议日期: 2009-10-18
出版日期: 2009-10-18
会议地点: 中国
其他题名: 血浆中溶血卵磷脂的轮廓分析:肺癌中生物标记物的发现及异构体的鉴定
通讯作者: 张秀莉 ;  梁鑫淼
部门归属: 十八室
主办者: 中国科学院大连化物所
摘要: Lysophosphatidylcholines (lysoPCs) are a class of special structure endogenous compounds, which have the same polar head with different fatty acyls in chain lengths, fatty acyl position, degrees of saturation and different double bond location(s). The amount of lysoPCs isomers between healthy people and patients can be a clinical diagnostic indicator which may help to reveal pathophysiological changes. In this work, a method was developed to discriminate the lysoPCs by using reversed phase ultra-performance liquid chromatography coupled to quadrupole-time of flight mass spectrometry (UPLC/Q-TOF) with the utility of MSE function. Isomeric lysoPCs were distinguished based on the retention time and the peak intensity ratio of product ions. 28 plasma lysoPCs species were identified from human plasma. The plasma samples of 12 patients with lung cancer and 12 healthy persons were collected and analyzed. With principal component analysis (PCA), the identified LysoPCs metabolic profiles of lung cancer were investigated. Both ESI+ and ESI- results showed that lung cancer patients had the same 5 lysoPCs metabolic abnormality, they are sn-1 lyso16:0, sn-2 lysoPC 16:0, sn-1 lysoPC 18:0, sn-1 lysoPC 18:1 and sn-2 lysoPC 18:2. It is noteworthy that the function of isomers with the different fatty acyls position or different double bond location(s) related to lung cancer is different. This may help elucidate the action mechanism of lung cancer.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/113884
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Dong J,Zhang XL,Cai XM,et al. Lysophosphatidylcholines profiling of plasma: isomers discrimination and biomarkers discovery in lung cancer[C]. 见:24th International Symposium on Microscale Bioseparations. 中国. 2009-10-18.
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