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学科主题物理化学
Synthesis and Characterization of Graft Copolymer Chitosan-g-MPEG and Surface Modification of Alginate/Chitosan/Alginate (ACA) Microcapsules
Zheng JN(郑佳妮); Xie HG(谢红国); Yu WT(于炜婷); Xie WY(谢威扬); Ma XJ(马小军)
会议名称The Second International Symposium on Surface and Interface of Biomaterials
会议日期2010-1-4
2010-01-04
会议地点中国
其他题名壳聚糖-g-甲氧基聚乙二醇接枝共聚物的合成和表征及其在海藻酸钠/壳聚糖/海藻酸钠微胶囊的表面修饰
页码124/1
部门归属十八室
主办者香港大学
英文摘要Alginate/chitosan/alginate (ACA) microcapsules made of natural polysaccharides have been widely investigated for cell transplantation because of their non-immunogenic, non-toxic, and biodegradable properties. However, protein adsorption onto the surface of microcapsules will happen after a long-term transplantation in vivo. Polyethylene glycol (PEG) with the unique properties of hydrophilicity, flexibility, shielding of substrate charges, and large exclusion volume has been widely used to reduce protein adsorption. Among the many approaches used to immobilize PEG on surfaces, PEG-grafted copolymers have been shown to spontaneously adsorb to oppositely charged surfaces. The high graft density will make the PEG side-chains like brushes extend from the surfaces to prevent protein adsorption [1]. Therefore, the aim of this work is to study the effects of the molecular weight of Methoxy-PEG (MPEG) and chitosan, the degree of substitution (DS) of the copolymers and the binding conditions on the amount of binding to make the graft density maximum.
语种中文
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/114010
专题中国科学院大连化学物理研究所
通讯作者Ma XJ(马小军)
推荐引用方式
GB/T 7714
Zheng JN,Xie HG,Yu WT,et al. Synthesis and Characterization of Graft Copolymer Chitosan-g-MPEG and Surface Modification of Alginate/Chitosan/Alginate (ACA) Microcapsules[C],2010:124/1.
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