Subject Area物理化学
Effect of Surface Morphology on Protein Adsorption onto Alginate-Chitosan-Alginate(ACA) Microcapsules
Xie HG(谢红国); Zheng JN(郑佳妮); Li XX(李晓霞); Xie WY(谢威扬); Wang F(王锋); Ma XJ(马小军)
Conference NameThe Second International Symposium on Surface and Interface of Biomaterials
Conference Date2010-1-4
Conference Place中国
Alternative Title表面粗糙度对蛋白在ACA微胶囊表面吸附的影响
Funding Organization香港大学
AbstractAlginate-chitosan-alginate (ACA) microcapsule has been widely studied as a device for the immuno-isolation and transplantation of living cells. However, long-term survival of the microencapsulated cell grafts and thus their potential clinical applications have been hampered by the pericapsular fibrotic overgrowth induced by adsorbed protein. Protein adsorption is a rather complex process and has been suggested to be influenced by several factors such as surface wettability, charge and morphology of materials. The effect of chemical compositions of biomaterial surface has already been studied experimentally and theoretically [1]. However, the effect of random surface roughness on protein adsorption is still not understood well.
Document Type会议论文
Corresponding AuthorMa XJ(马小军)
Recommended Citation
GB/T 7714
Xie HG,Zheng JN,Li XX,et al. Effect of Surface Morphology on Protein Adsorption onto Alginate-Chitosan-Alginate(ACA) Microcapsules[C],2010:168/1.
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