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学科主题: 物理化学
题名: Fabrication of C18-silica hybrid monolithic capillary column using organic monomer and alkoxysilane
作者: Wu MH(吴明火) ;  Zhang ZB(张振斌) ;  Wu RA(吴仁安) ;  Wang FJ(王方军) ;  Zou HF(邹汉法)
会议名称: 25th International Symposium on Microscale Bioseparations MSB 2010
会议日期: 2002-3-21
出版日期: 2002-03-21
会议地点: 捷克
通讯作者: 邹汉法
部门归属: 十八室
主办者: 捷克分析化学研究所
摘要: A C18-silica hybrid monolithic column was prepared via the “one-pot” process. In which, the alkoxysilanes precursors of tetramethoxysilane (TMOS) and vinyltrimethoxysilane (VTMS) was firstly hydrolyzed in a 0.01 M acetic acid solution, and then the organic monomer of N-(2-(methacryloyloxy)-ethyl)-dimethyl- octadecylammonium bromide (MDOAB) for introducing the C18 moiety to the monolith along with the initiator of AIBN were added into the hydrolyzed solution. After sonicated for 15 min, the mixture was introduced into a pretreated capillary. The polycondensation of alkoxysilanes and the copolymerization of organic monomers and as-precondensed siloxanes were subsequently carried out at proper reaction conditions. The morphologies of the synthesized organic-silica hybrid monolithic columns were characterized by scanning electron microscopy (SEM). The performances of the resultant C18-silica monolithic columns were investigated by capillary electrochromatography (CEC) and the results confirmed that the MDOAB was successfully incorporated into the silica monolithic matrix. Furthermore, the C18-silica hybrid capillary monolithic column was applied in the analysis of BSA digest by μLC-MS/MS to demonstrate its potentials in proteome analysis.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/114036
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Wu MH,Zhang ZB,Wu RA,et al. Fabrication of C18-silica hybrid monolithic capillary column using organic monomer and alkoxysilane[C]. 见:25th International Symposium on Microscale Bioseparations MSB 2010. 捷克. 2002-3-21.
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