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学科主题: 物理化学
题名: Where and how to 'fish' disease-related metabolite biomarkers by using LC-MS based metabonomics
作者: Xu GW(许国旺) ;  Wang WZ(王文昭) ;  Yin PY(尹佩源) ;  Huang Q(黄强) ;  Zhao XJ(赵新捷) ;  Chen SL(陈世礼) ;  Chen J(陈静) ;  Zhou LN(周丽娜) ;  Kong HW(孔宏伟) ;  Lu X(路鑫)
会议名称: The Metabolomics conference 2010
会议日期: 2010-6-25
出版日期: 2010-06-25
会议地点: 荷兰
通讯作者: 许国旺
部门归属: 十八室
主办者: 国际代谢组学学会
摘要: Complex diseases such as cancer, diabetes and obesity arise from an intricate interaction of inherited–nature and environmental–nurture factors. Their (early) diagnosis is very difficult, especially based on only singular biomarker. The move toward \"multi biomarkers\" is a necessity. Metabonomics is a technique based on analyzing as many endogenetic metabolites as possible. It has shown the great potential of finding biomarker group for disease diagnosis. Normally Blood and urine are the best samples for clinical assay or metabonomics. Unfortunately, they are similar to a reservoir, any physiological and pathological changes will be integrated into urine or blood, the discovery of biomarkers taking them as samples become very difficult. To resolve this disadvantage, we are using the strategy from tissue to body fluids, from bile to blood and from animal models to human to ‘fish’ the potential metabolite biomarkers. Based on it, it is possible to find the potential biomarkers from tissue, bile or animal, then to validate them in human body fluids, it can reduce the disturbance of other non-pathological factors, in the meantime find early diagnosis biomarkers which are usually difficult in human samples because of the difficult in early diagnosis. As the examples, we shall report our newest work on the metabolic biomarker discovery of liver cancer by using non-target metabonomics analysis to ‘fish’ the potential differential metabolites from the tissue, bile or animal model based on LC-MS/MS, and target metabolic analysis in human serum/plasma to confirm the found biomarker group based on selective ion LC-MS or MRM LC-MS.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/114122
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Xu GW,Wang WZ,Yin PY,et al. Where and how to 'fish' disease-related metabolite biomarkers by using LC-MS based metabonomics[C]. 见:The Metabolomics conference 2010. 荷兰. 2010-6-25.
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