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学科主题: 物理化学
题名: Synthesis and characterization of amphiphilic chitosan derivatives as a nano-carrier for paclitaxel delivery
作者: Zhou HF(周火飞) ;  Liu XD(刘袖洞) ;  Guo X(郭昕) ;  Li N(李楠) ;  Yu WT(于伟婷) ;  Zhang Y(张英) ;  Ma XJ(马小军)
会议名称: Symposium on Innovative Polymers for Controlled Delivery
会议日期: 2010-9-14
出版日期: 2010-09-14
会议地点: 中国
通讯作者: 马小军
ISSN: 978-7-81137-581-7
部门归属: 十八室
主办者: 苏州大学
摘要: A series of amphiphilic chitosan derivatives has been synthesized by grafting deoxycholic acid and hydrophilic molecules containing glycidyl group for application in drug delivery. These chitosan derivatives formed stable nanoparticles with sizes ranging from 160-240 nm and zeta potential ranging from 0-25mV respectively in PBS. Paclitaxel (PTX) LOADED nanoparticles, showed a sustained and controlled release behaviour. Furthermore, the nanoparticles can be easily delivered into tumor cells.
语种: 中文
Citation statistics: 
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/114478
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Zhou HF,Liu XD,Guo X,et al. Synthesis and characterization of amphiphilic chitosan derivatives as a nano-carrier for paclitaxel delivery[C]. 见:Symposium on Innovative Polymers for Controlled Delivery. 中国. 2010-9-14.
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