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学科主题: 物理化学
题名: Study on bisilisification based on the recombinant silicatein of marin sponge hymeniacidon perlevis
作者: Cao XP(曹旭鹏) ;  Cao H(曹恒) ;  Xue S(薛松)
会议名称: VIII WORLD SPONGE CONFERENCE 2010
会议日期: 2010-9-20
出版日期: 2010-09-20
会议地点: 西班牙
其他题名: 基于繁茂膜海绵重组硅蛋白的生物硅化研究
通讯作者: 曹旭鹏
部门归属: 十八室
主办者: 西班牙
摘要: Sponges (Porifera) are the oldest living metazoan in the world, among which most of them (Demospongia) can produce silicic skeleton from orthosilicic acid in the seawater under the natural environmental conditions. These biosilicic materials exhibit good mechanical and optical properties as well as good biocompatibility. During the biosilicification process of sponges, a protein, named as silicatein, plays an important role and has attracted great attention from biologist, chemists and material scientists. Biosilicification process of Hymeniacidon perlevis had been investigated on both in field and lab culture of sponge tissues as well as in vitro sponge cell culture. It had been shown that the expression of silicatein had a strong correlation with the growth status of sponge or sponge cell cultures. But till now, no direct proof had been report for the mechanism of the biosilicification catalyzed by silicatein from the view of protein structures. The popular mechanism for this process was speculated from the structure of cathepsin L, which is considered in the same superfamily with silicatein. Here we hope to use the technology of structural biology and silicatein of H.perlevis as the model to illustration the mechanism of this process. And based on the structure of the active center of silicatein to construct suitable recombinant silicatein for developing their application.
语种: 中文
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/114490
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Cao XP,Cao H,Xue S. Study on bisilisification based on the recombinant silicatein of marin sponge hymeniacidon perlevis[C]. 见:VIII WORLD SPONGE CONFERENCE 2010. 西班牙. 2010-9-20.
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