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学科主题: 物理化学
题名: Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells
作者: Li, Ruibin1;  Wu, Ren'an1;  Zhao, Liang1;  Hu, Zhengyan1;  Guo, Shujing2;  Pan, Xiulian2;  Zou, Hanfa1
通讯作者: 吴仁安
刊名: CARBON
发表日期: 2011-04-01
DOI: 10.1016/j.carbon.2011.01.003
卷: 49, 期:5, 页:1797-1805
收录类别: SCI
文章类型: Article
部门归属: 18;5
项目归属: 1809;502
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Physical ;  Materials Science, Multidisciplinary
摘要: Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells
研究领域[WOS]: Chemistry ;  Materials Science
英文摘要: A nanomaterial, folate and iron difunctionalized multiwall carbon nanotube (FA-MWCNT@Fe), has been synthesized by conjugating folate and iron nanoparticles with oxidized multi-walled carbon nanotubes, and applied as a dual-targeted drug nanocarrier to deliver doxorubicin into HeLa cells with the assistance of an external magnetic field. The prepared FA-MWCNT@Fe was characterized by X-ray diffraction, transmission electron microscopy and infrared spectroscopy. This nanocarrier has a sufficient load capacity (doxorubicin/FA-MWCNT@Fe, 32 mu g/mg) and a prolonged release property controlled by near infrared radiation. It also demonstrated both biologically (active) and magnetically (passive) targeting capabilities toward HeLa cells in vitro with ca. 6-fold higher delivery efficiency of doxorubicin than free doxorubicin. (C) 2011 Elsevier Ltd. All rights reserved.
关键词[WOS]: CORE-SHELL NANOPARTICLES ;  INTRACELLULAR DELIVERY ;  CONTROLLED-RELEASE ;  FUNCTIONALIZATION ;  TRANSPORTERS ;  DESIGN ;  BIOAPPLICATIONS ;  DOXORUBICIN ;  DISCOVERY ;  THERAPY
语种: 英语
WOS记录号: WOS:000287952700034
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115190
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Li, Ruibin,Wu, Ren'an,Zhao, Liang,et al. Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells[J]. CARBON,2011,49(5):1797-1805.
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