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学科主题: 物理化学
题名: Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei
作者: Xu, Xiao-Hui1, 2;  Zhang, Wei1, 3, 4;  Cao, Xu-Peng1;  Xue, Song1
通讯作者: 张卫
关键词: Abietane diterpenoids ;  Elicitation ;  In situ product removal ;  Cephalotaxus fortunei ;  Cell suspension culture
刊名: PHYTOCHEMISTRY LETTERS
发表日期: 2011-03-15
DOI: 10.1016/j.phytol.2010.12.003
卷: 4, 期:1, 页:52-55
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1812
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Plant Sciences
摘要: Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei
研究领域[WOS]: Biochemistry & Molecular Biology ;  Plant Sciences
英文摘要: Cell suspension cultures of Cephalotaxus fortunei were manipulated to produce secondary metabolites of pharmaceutical interest. Seven abietane diterpenoids (six known and one new) were produced by the suspension-cultured C. fortunei cells by complementing an elicitation strategy with an in situ product removal strategy. Based on the results of spectrometric analysis, the structure of the new compound was determined to be 20(10 -> 5)-abeo-4,5-seco-5(10), 6,8,11,13-abietapentaene-3-one (1). The six known compounds were identified as 12-hydroxyabieta-6,8,11,13-tetraene-3-one (2), abieta-8,11,13-triene-3 beta, 12-diol (hinokiol) (3), abietatriene-3 beta-ol (4), 11,12-dihydroxy-8,11,13-abietatriene-3,7-dione (5), 11-hydroxy-12-methoxyabieta-8,11,13-triene-3,7-dione (6), and 3 beta, 11-dihydroxy-12-methoxyabieta-8,11,13- triene-7-one (7). This is the first time that diterpenoids have been isolated and identified from this pharmaceutically important plant. These results suggest that the strategies we applied were effective methods for synthesizing abietane diterpenoids via a suspension culture of C. fortunei cells. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
关键词[WOS]: SECONDARY METABOLITES ;  CALLUS ;  HOMOHARRINGTONINE ;  HARRINGTONINE ;  YUNNANENSIS
语种: 英语
WOS记录号: WOS:000287850100010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115192
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Flinders Univ S Australia, Flinders Ctr Marine Bioproc & Bioprod, Adelaide, SA 5042, Australia
4.Flinders Univ S Australia, Dept Med Biotechnol, Sch Med, Adelaide, SA 5042, Australia

Recommended Citation:
Xu, Xiao-Hui,Zhang, Wei,Cao, Xu-Peng,et al. Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei[J]. PHYTOCHEMISTRY LETTERS,2011,4(1):52-55.
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