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学科主题物理化学
Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei
Xu, Xiao-Hui1,2; Zhang, Wei1,3,4; Cao, Xu-Peng1; Xue, Song1; Zhang W(张卫)
关键词Abietane Diterpenoids Elicitation In Situ Product Removal Cephalotaxus Fortunei Cell Suspension Culture
刊名PHYTOCHEMISTRY LETTERS
2011-03-15
ISSN待补充
DOI10.1016/j.phytol.2010.12.003
4期:1页:52-55
收录类别SCI
文章类型Article
部门归属18
项目归属1812
产权排名1,1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]SECONDARY METABOLITES ; CALLUS ; HOMOHARRINGTONINE ; HARRINGTONINE ; YUNNANENSIS
英文摘要Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei; Cell suspension cultures of Cephalotaxus fortunei were manipulated to produce secondary metabolites of pharmaceutical interest. Seven abietane diterpenoids (six known and one new) were produced by the suspension-cultured C. fortunei cells by complementing an elicitation strategy with an in situ product removal strategy. Based on the results of spectrometric analysis, the structure of the new compound was determined to be 20(10 -> 5)-abeo-4,5-seco-5(10), 6,8,11,13-abietapentaene-3-one (1). The six known compounds were identified as 12-hydroxyabieta-6,8,11,13-tetraene-3-one (2), abieta-8,11,13-triene-3 beta, 12-diol (hinokiol) (3), abietatriene-3 beta-ol (4), 11,12-dihydroxy-8,11,13-abietatriene-3,7-dione (5), 11-hydroxy-12-methoxyabieta-8,11,13-triene-3,7-dione (6), and 3 beta, 11-dihydroxy-12-methoxyabieta-8,11,13- triene-7-one (7). This is the first time that diterpenoids have been isolated and identified from this pharmaceutically important plant. These results suggest that the strategies we applied were effective methods for synthesizing abietane diterpenoids via a suspension culture of C. fortunei cells. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000287850100010
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/115192
专题中国科学院大连化学物理研究所
通讯作者Zhang W(张卫)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Flinders Univ S Australia, Flinders Ctr Marine Bioproc & Bioprod, Adelaide, SA 5042, Australia
4.Flinders Univ S Australia, Dept Med Biotechnol, Sch Med, Adelaide, SA 5042, Australia
推荐引用方式
GB/T 7714
Xu, Xiao-Hui,Zhang, Wei,Cao, Xu-Peng,et al. Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei[J]. PHYTOCHEMISTRY LETTERS,2011,4(1):52-55.
APA Xu, Xiao-Hui,Zhang, Wei,Cao, Xu-Peng,Xue, Song,&张卫.(2011).Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei.PHYTOCHEMISTRY LETTERS,4(1),52-55.
MLA Xu, Xiao-Hui,et al."Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei".PHYTOCHEMISTRY LETTERS 4.1(2011):52-55.
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