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学科主题: 物理化学
题名: Nanofiber-modified surface directed cell migration and orientation in microsystem
作者: Zhang, Xu1, 2;  Gao, Xinghua1, 2;  Jiang, Lei1;  Zhang, Xulang1;  Qin, Jianhua1
通讯作者: 秦建华
关键词: bioMEMS ;  cellular biophysics ;  electrospinning ;  microfluidics ;  nanobiotechnology ;  nanofibres ;  polymer fibres ;  surface structure ;  tissue engineering
刊名: BIOMICROFLUIDICS
发表日期: 2011-09-01
DOI: 10.1063/1.3614457
卷: 5, 期:3, 页:032007
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1807
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Biophysics ;  Nanoscience & Nanotechnology ;  Physics, Fluids & Plasmas
摘要: Nanofiber-modified surface directed cell migration and orientation in microsystem
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Science & Technology - Other Topics ;  Physics
英文摘要: Cell-microscale pattern surface interactions are crucial to understand many fundamental biological questions and develop regenerative medicine and tissue engineering approaches. In this work, we demonstrated a simple method to pattern PDMS surface by sacrificing poly vinyl pyrrolidone (PVP) electrospinning nanofibers and investigated the growth profile of cells on the modified patterned surfaces using stroma cells. The stromal cells were observed to exhibit good viability on this modified surface and the patterned surface with alignment nanofibers could promote cell migration. Furthermore, the modified PDMS surface was integrated with microfluidic channels to create the microscale spatial factor and was used to explore the cell migration and orientation under this microsystem. Both spatial factor and patterned surfaces were found to contribute to the complex cell orientation under the combined dual effects. This established method is simple, fast, and easy for use, demonstrating the potential of this microsystem for applications in addressing biological questions in complex environment. (C) 2011 American Institute of Physics. [doi:10.1063/1.3614457]
关键词[WOS]: DIP-PEN NANOLITHOGRAPHY ;  PATTERNS ;  ADHESION ;  DIFFERENTIATION ;  SUBSTRATE ;  PROTEIN ;  FIBERS ;  FORCE
语种: 英语
WOS记录号: WOS:000295618500009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115294
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Zhang, Xu,Gao, Xinghua,Jiang, Lei,et al. Nanofiber-modified surface directed cell migration and orientation in microsystem[J]. BIOMICROFLUIDICS,2011,5(3):032007.
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