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学科主题物理化学
Selective separation of flavonoid glycosides in Dalbergia odorifera by matrix solid-phase dispersion using titania
Xu, Lingyan1; Shi, Hui1; Liang, Tu1; Feng, Jiatao2; Jin, Yu1; Ke, Yanxiong1; Liang, Xinmiao1,2; Ke YX(柯燕雄)
关键词Dalbergia Odorifera Flavonoid Glycosides Matrix Solid-phase Dispersion Selective Separation Titania
刊名JOURNAL OF SEPARATION SCIENCE
2011-06-01
ISSN待补充
DOI10.1002/jssc.201100024
34期:11页:1347-1354
收录类别SCI
文章类型Article
部门归属18
项目归属1803
产权排名2,4
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; IONIZATION MASS-SPECTROMETRY ; ION CHROMATOGRAPHY ; HPLC ; PHOSPHOPEPTIDES ; EXTRACTION ; BEHAVIOR ; COLUMN
英文摘要Selective separation of flavonoid glycosides in Dalbergia odorifera by matrix solid-phase dispersion using titania; Dalbergia odorifera contains high concentrations of flavonoid aglycones and trace flavonoid glycosides. In this study, trace flavonoid glycosides were separated from D. odorifera by titania with matrix solid-phase dispersion (MSPD). Before the MSPD experiment, four standards, including two isoflavone glycosides (genistin and formononetin-8-C-apiosyl (1-6)-glucoside) and their aglycones (genistein and formononetin), were used to compare their retention on a titania column. The effect of acetonitrile concentration and pH on their retention was investigated and a conclusion was drawn that high acetonitrile concentration and pH lead to the greatest difference in the retention of flavonoid as glycosides and aglycones. Besides hydrophilic interaction and ligand-exchange interaction may exist between sugar moiety of flavonoid glycoside and titania, so that flavonoid glycosides have stronger retention than that of aglycones. Based on the chromatographic rule of flavonoid as glycosides and aglycones on the titania column, the MSPD method was optimized to elute high concentration flavonoid aglycones first with 90% acetonitrile and 10% water containing 100 mM ammonium acetate buffer, and then to elute trace flavonoid glycosides with 20% acetonitrile and 80% water containing 1% trifluoroacetate (TFA). Isolated flavonoid glycosides were further analyzed by UPLC-MS/MS, and their fragmentation in MS 2 showed they are C-glycosyl flavonoids.
语种英语
WOS记录号WOS:000291346400017
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/115336
专题中国科学院大连化学物理研究所
通讯作者Ke YX(柯燕雄)
作者单位1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian, Peoples R China
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GB/T 7714
Xu, Lingyan,Shi, Hui,Liang, Tu,et al. Selective separation of flavonoid glycosides in Dalbergia odorifera by matrix solid-phase dispersion using titania[J]. JOURNAL OF SEPARATION SCIENCE,2011,34(11):1347-1354.
APA Xu, Lingyan.,Shi, Hui.,Liang, Tu.,Feng, Jiatao.,Jin, Yu.,...&柯燕雄.(2011).Selective separation of flavonoid glycosides in Dalbergia odorifera by matrix solid-phase dispersion using titania.JOURNAL OF SEPARATION SCIENCE,34(11),1347-1354.
MLA Xu, Lingyan,et al."Selective separation of flavonoid glycosides in Dalbergia odorifera by matrix solid-phase dispersion using titania".JOURNAL OF SEPARATION SCIENCE 34.11(2011):1347-1354.
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