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学科主题: 物理化学
题名: A new method for chemical identification based on orthogonal parallel liquid chromatography separation and accurate molecular weight confirmation
作者: Zeng, Jing1;  Zhang, Xiuli1;  Guo, Zhimou1;  Feng, Jiatao1;  Xue, Xingya1;  Liang, Xinmiao1
通讯作者: 薛兴亚 ;  梁鑫淼
关键词: Orthogonal parallel separation ;  Retention time ;  Accurate molecular weight ;  Chemical identification ;  Flavonoids ;  Library searching
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2011-04-01
DOI: 10.1016/j.chroma.2011.01.079
卷: 1218, 期:13, 页:1749-1755
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
摘要: A new method for chemical identification based on orthogonal parallel liquid chromatography separation and accurate molecular weight confirmation
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Recent advances in the theory and application of orthogonal LC separation have allowed for the establishment of a more effective method for the chemical identification of target compounds in complex samples, especially structurally similar compounds. In this study, a new chemical identification method based on orthogonal parallel separation and accurate molecular weight confirmation was developed. An orthogonal separation system consisting of an XTerra MS C-18 column, a home-made Click OEG column, and a Click CD column was established for separation and identification. In addition, 82 flavonoids were selected as references, to be used for the construction of a library. Retention times of each reference flavonoid on each column and accurate molecular weights were recorded and imported into a searchable library as "tags" for the unknown screening. For the method validation, two complex mixtures, fractions of Dalbergia odorifera T. Chen and Scutellaria baicalensis Georgi, specifically, were separated and identified. In total, nine compounds were unequivocally identified by retention time and confirmation of accurate molecular weight, demonstrating that this method is suitable and efficient for the chemical identification of complex samples. (C) 2011 Elsevier B.V. All rights reserved.
关键词[WOS]: INTER-LABORATORY TRANSFERABILITY ;  TANDEM MASS-SPECTROMETRY ;  OLIGO(ETHYLENE GLYCOL) ;  RAPID IDENTIFICATION ;  QUALITATIVE-ANALYSIS ;  STATIONARY-PHASE ;  SPECTRAL LIBRARY ;  SYSTEM ;  COLUMN ;  DRUGS
语种: 英语
WOS记录号: WOS:000288837400008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115344
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Lab Nat Med, Dalian 116023, Liaoning Prov, Peoples R China

Recommended Citation:
Zeng, Jing,Zhang, Xiuli,Guo, Zhimou,et al. A new method for chemical identification based on orthogonal parallel liquid chromatography separation and accurate molecular weight confirmation[J]. JOURNAL OF CHROMATOGRAPHY A,2011,1218(13):1749-1755.
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