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学科主题物理化学
Analysis of cephalosporins by hydrophilic interaction chromatography
Liu, Qiaoxia1; Xu, Lingyan1; Ke, Yanxiong1; Jin, Yu1; Zhang, Feifang1; Liang, Xinmiao1,2; Jin Y(金郁); Zhang FF(章飞芳)
关键词Cephalosporins Hydrophilic Interaction Chromatography The Click Beta-cd Column Reversed-phase High Performance Liquid Chromatography
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2011-02-20
ISSN待补充
DOI10.1016/j.jpba.2010.09.040
54期:3页:623-628
收录类别SCI
文章类型Article
部门归属18
项目归属1803
产权排名2,6
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; ELECTROSPRAY MASS-SPECTROMETRY ; REVERSED-PHASE ; ION-EXCHANGE ; POLAR COMPOUNDS ; DRUG DISCOVERY ; SEPARATION ; URINE ; MODE
英文摘要Analysis of cephalosporins by hydrophilic interaction chromatography; A simple hydrophilic interaction chromatography (HILIC) method was developed to analyze seven cephalosporins. These seven cephalosporins could be separated well on the Click beta-CD column and Atlantis HILIC Silica column. The effects of buffer concentration and pH on the retention under HILIC mode were studied. Except cefepime hydrochloride (4), the retention of other six cephalosporins increased with increasing buffer concentration, while decreased with increasing pH. Different separation selectivities could be observed on the Click beta-CD column and Atlantis HILIC Silica column, and changing pH also resulted in the changing of separation selectivity. The separations of cephalosporins by HILIC and reversed-phase high performance liquid chromatography (RP-HPLC) were compared, and the two separation modes had good orthogonality. In addition, cefotaxime sodium (1) and its degradation were separated well on the Click beta-CD column, which indicated that the Click beta-CD column by HILIC can be used for studying the stability of cephalosporins. (C) 2010 Published by Elsevier B.V.
语种英语
WOS记录号WOS:000284814300033
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/115356
专题中国科学院大连化学物理研究所
通讯作者Jin Y(金郁); Zhang FF(章飞芳)
作者单位1.E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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GB/T 7714
Liu, Qiaoxia,Xu, Lingyan,Ke, Yanxiong,et al. Analysis of cephalosporins by hydrophilic interaction chromatography[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,54(3):623-628.
APA Liu, Qiaoxia.,Xu, Lingyan.,Ke, Yanxiong.,Jin, Yu.,Zhang, Feifang.,...&章飞芳.(2011).Analysis of cephalosporins by hydrophilic interaction chromatography.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,54(3),623-628.
MLA Liu, Qiaoxia,et al."Analysis of cephalosporins by hydrophilic interaction chromatography".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 54.3(2011):623-628.
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