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学科主题: 物理化学
题名: Analysis of cephalosporins by hydrophilic interaction chromatography
作者: Liu, Qiaoxia1;  Xu, Lingyan1;  Ke, Yanxiong1;  Jin, Yu1;  Zhang, Feifang1;  Liang, Xinmiao1, 2
通讯作者: 金郁 ;  章飞芳
关键词: Cephalosporins ;  Hydrophilic interaction chromatography ;  The Click beta-CD column ;  Reversed-phase high performance liquid chromatography
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2011-02-20
DOI: 10.1016/j.jpba.2010.09.040
卷: 54, 期:3, 页:623-628
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 2,6
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
摘要: Analysis of cephalosporins by hydrophilic interaction chromatography
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: A simple hydrophilic interaction chromatography (HILIC) method was developed to analyze seven cephalosporins. These seven cephalosporins could be separated well on the Click beta-CD column and Atlantis HILIC Silica column. The effects of buffer concentration and pH on the retention under HILIC mode were studied. Except cefepime hydrochloride (4), the retention of other six cephalosporins increased with increasing buffer concentration, while decreased with increasing pH. Different separation selectivities could be observed on the Click beta-CD column and Atlantis HILIC Silica column, and changing pH also resulted in the changing of separation selectivity. The separations of cephalosporins by HILIC and reversed-phase high performance liquid chromatography (RP-HPLC) were compared, and the two separation modes had good orthogonality. In addition, cefotaxime sodium (1) and its degradation were separated well on the Click beta-CD column, which indicated that the Click beta-CD column by HILIC can be used for studying the stability of cephalosporins. (C) 2010 Published by Elsevier B.V.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  ELECTROSPRAY MASS-SPECTROMETRY ;  REVERSED-PHASE ;  ION-EXCHANGE ;  POLAR COMPOUNDS ;  DRUG DISCOVERY ;  SEPARATION ;  URINE ;  MODE
语种: 英语
WOS记录号: WOS:000284814300033
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115356
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Liu, Qiaoxia,Xu, Lingyan,Ke, Yanxiong,et al. Analysis of cephalosporins by hydrophilic interaction chromatography[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,54(3):623-628.
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