DICP OpenIR
Subject Area物理化学
Analysis of cephalosporins by hydrophilic interaction chromatography
Liu, Qiaoxia1; Xu, Lingyan1; Ke, Yanxiong1; Jin, Yu1; Zhang, Feifang1; Liang, Xinmiao1,2; Jin Y(金郁); Zhang FF(章飞芳)
KeywordCephalosporins Hydrophilic Interaction Chromatography The Click Beta-cd Column Reversed-phase High Performance Liquid Chromatography
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2011-02-20
ISSN待补充
DOI10.1016/j.jpba.2010.09.040
Volume54Issue:3Pages:623-628
Indexed BySCI
SubtypeArticle
Department18
Funding Project1803
Contribution Rank2,6
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; ELECTROSPRAY MASS-SPECTROMETRY ; REVERSED-PHASE ; ION-EXCHANGE ; POLAR COMPOUNDS ; DRUG DISCOVERY ; SEPARATION ; URINE ; MODE
AbstractAnalysis of cephalosporins by hydrophilic interaction chromatography; A simple hydrophilic interaction chromatography (HILIC) method was developed to analyze seven cephalosporins. These seven cephalosporins could be separated well on the Click beta-CD column and Atlantis HILIC Silica column. The effects of buffer concentration and pH on the retention under HILIC mode were studied. Except cefepime hydrochloride (4), the retention of other six cephalosporins increased with increasing buffer concentration, while decreased with increasing pH. Different separation selectivities could be observed on the Click beta-CD column and Atlantis HILIC Silica column, and changing pH also resulted in the changing of separation selectivity. The separations of cephalosporins by HILIC and reversed-phase high performance liquid chromatography (RP-HPLC) were compared, and the two separation modes had good orthogonality. In addition, cefotaxime sodium (1) and its degradation were separated well on the Click beta-CD column, which indicated that the Click beta-CD column by HILIC can be used for studying the stability of cephalosporins. (C) 2010 Published by Elsevier B.V.
Language英语
WOS IDWOS:000284814300033
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/115356
Collection中国科学院大连化学物理研究所
Corresponding AuthorJin Y(金郁); Zhang FF(章飞芳)
Affiliation1.E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Liu, Qiaoxia,Xu, Lingyan,Ke, Yanxiong,et al. Analysis of cephalosporins by hydrophilic interaction chromatography[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,54(3):623-628.
APA Liu, Qiaoxia.,Xu, Lingyan.,Ke, Yanxiong.,Jin, Yu.,Zhang, Feifang.,...&章飞芳.(2011).Analysis of cephalosporins by hydrophilic interaction chromatography.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,54(3),623-628.
MLA Liu, Qiaoxia,et al."Analysis of cephalosporins by hydrophilic interaction chromatography".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 54.3(2011):623-628.
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