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学科主题物理化学
Preparation and evaluation of hydrophilic C18 monolithic sorbents for enhanced polar compound retention in liquid chromatography and solid phase extraction
Li, Yun1; Xie, Xin1; Lee, Milton L.2; Chen, Jiping1; Chen JP(陈吉平)
关键词Solid Phase Extraction Capillary Liquid Chromatography Monolithic C18 Hydrophilic Phenols
刊名JOURNAL OF CHROMATOGRAPHY A
2011-12-02
ISSN待补充
DOI10.1016/j.chroma.2011.09.070
1218期:48页:8608-8616
收录类别SCI
文章类型Article
部门归属1
项目归属103
产权排名1,1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]SIZE-EXCLUSION CHROMATOGRAPHY ; POROUS POLYMER MONOLITHS ; MASS-SPECTROMETRY ; STATIONARY-PHASE ; NEW-GENERATION ; COLUMNS ; SEPARATION ; ELECTROPHORESIS ; PROTEINS ; COATINGS
英文摘要Preparation and evaluation of hydrophilic C18 monolithic sorbents for enhanced polar compound retention in liquid chromatography and solid phase extraction; Hydrophilic C18 monolithic polymer sorbents were synthesized for use in solid phase extraction (SPE) and in capillary liquid chromatography (LC). The approach involved incorporating both hydrophobic and hydrophilic monomers into a monolithic material, by copolymerization of stearyl methacrylate (SMA), poly(ethylene glycol) methyl ether methacrylate (PEGMEMA) and ethylene dimethacrylate (EDMA) in the presence of selected porogens, to produce translucent mesoporous monolithic materials in bulk (SPE) or white macroporous monoliths inside fused silica capillary columns (capillary LC). A capillary column containing one of the hydrophilic C18 monoliths (i.e. poly(SMA-co-PEGMEMA-co-EDMA) with 15% (w/w) PEGMEMA) demonstrated nearly 35% reduction in retention of polycyclic aromatic compounds and greater than 40% increase in retention of phenols compared to a hydrophobic Cl 8 monolithic column. In addition, the hydrophilic monolith demonstrated significantly improved resolution of phenols. Similar monolithic materials prepared in bulk were ground and sieved to obtain 45-65 mu m particles with desired rigidity for SPE. To achieve optimum extraction performance for phenols, several parameters, including sample pH and volume, and eluent type and volume, were investigated. Under optimized experimental conditions, the method demonstrated good sensitivity (1.6 ng/mL LOD) and linearity (R(2) > 0.97 for 10-200 ng/mL). Again, incorporation of 15% (w/w) PEGMEMA in the monolith increased the extraction efficiency of phenols in water from approximately 20% to 67-92% compared to a hydrophobic C18 monolithic material. Increased wettability of the sorbent by the aqueous sample matrix and the presence of hydrogen-bonding interactions are responsible for the improved retention of polar compounds. (C) 2011 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000297386500006
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/115467
专题中国科学院大连化学物理研究所
通讯作者Chen JP(陈吉平)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA
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Li, Yun,Xie, Xin,Lee, Milton L.,et al. Preparation and evaluation of hydrophilic C18 monolithic sorbents for enhanced polar compound retention in liquid chromatography and solid phase extraction[J]. JOURNAL OF CHROMATOGRAPHY A,2011,1218(48):8608-8616.
APA Li, Yun,Xie, Xin,Lee, Milton L.,Chen, Jiping,&陈吉平.(2011).Preparation and evaluation of hydrophilic C18 monolithic sorbents for enhanced polar compound retention in liquid chromatography and solid phase extraction.JOURNAL OF CHROMATOGRAPHY A,1218(48),8608-8616.
MLA Li, Yun,et al."Preparation and evaluation of hydrophilic C18 monolithic sorbents for enhanced polar compound retention in liquid chromatography and solid phase extraction".JOURNAL OF CHROMATOGRAPHY A 1218.48(2011):8608-8616.
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