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学科主题物理化学
Electrochemical DNA biosensor for screening of chlorinated benzene pollutants
Wu, Lidong; Lu, Xianbo; Jin, Jing; Zhang, Haijun; Chen, Jiping1; Chen JP(陈吉平)
关键词Chlorinated Benzenes Electrochemical Oligonucleotide Biosensor Screening Toxicity Evaluation Environmental Monitoring
刊名BIOSENSORS & BIOELECTRONICS
2011-06-15
ISSN待补充
DOI10.1016/j.bios.2011.03.027
26期:10页:4040-4045
收录类别SCI
文章类型Article
部门归属1
项目归属103
产权排名1,1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
研究领域[WOS]Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
关键词[WOS]CHRONIC MYELOGENOUS LEUKEMIA ; HEPATITIS-B-VIRUS ; METHYLENE-BLUE ; HYBRIDIZATION INDICATOR ; GOLD ; MONOLAYERS ; TRANSPORT ; ELECTRODE ; TOXICITY ; QSAR
英文摘要Electrochemical DNA biosensor for screening of chlorinated benzene pollutants; In this work, an electrochemical DNA biosensor based on double-stranded DNA modified Au electrode (dsDNA/Au) was proposed for the rapid screening and detection of chlorinated benzenes pollutants, in which redox-active methylene blue (MB) was used to amplify the interaction between dsDNA and the target analyte. Using hexachlorobenzene (HCB) as a model analyte of chlorinated benzenes, the biosensor demonstrated a linear response with the logarithm of HCB concentrations from 100 pmol L(-1) to 100 nmol L(-1). The obtained detection limit was 30 pmol L(-1), which was remarkably superior to other biosensors. The interaction mechanism of the biosensor with HCB was proposed based on systematical characterization by cyclic voltammetry (CV), differential pulse voltammetry (Dry), UV-vis spectrometry and electrochemical quartz crystal microbalance (EQCM). Further studies revealed that the biosensor could screen chlorinated benzenes in the presence of 100 fold amount of other co-existing chemicals (ethyl acetate and sodium oxalate, etc.), and the response signal of the biosensors for different chlorinated benzenes was correlative to their respective toxicity. The proposed biosensor proved to be a promising "alarm" tool for rapid screening of chlorinated benzenes in real water samples. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000291904000010
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/115470
专题中国科学院大连化学物理研究所
通讯作者Chen JP(陈吉平)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Wu, Lidong,Lu, Xianbo,Jin, Jing,et al. Electrochemical DNA biosensor for screening of chlorinated benzene pollutants[J]. BIOSENSORS & BIOELECTRONICS,2011,26(10):4040-4045.
APA Wu, Lidong,Lu, Xianbo,Jin, Jing,Zhang, Haijun,Chen, Jiping,&陈吉平.(2011).Electrochemical DNA biosensor for screening of chlorinated benzene pollutants.BIOSENSORS & BIOELECTRONICS,26(10),4040-4045.
MLA Wu, Lidong,et al."Electrochemical DNA biosensor for screening of chlorinated benzene pollutants".BIOSENSORS & BIOELECTRONICS 26.10(2011):4040-4045.
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