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学科主题: 物理化学
题名: Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress
作者: Qiao, Ying1, 2;  Bai, Xue-Fang1;  Du, Yu-Guang1
通讯作者: 杜昱光
关键词: Sepsis ;  Lipopolysaccharide ;  Chitosan oligosaccharides ;  INF-alpha ;  Lipid peroxidation
刊名: INTERNATIONAL IMMUNOPHARMACOLOGY
发表日期: 2011
DOI: 10.1016/j.intimp.2010.10.016
卷: 11, 期:1, 页:121-127
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Immunology ;  Pharmacology & Pharmacy
摘要: Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress
研究领域[WOS]: Immunology ;  Pharmacology & Pharmacy
英文摘要: Sepsis and its derivative syndromes are major causes of morbidity and mortality in the intensive care unit. Recently, lots of studies have shown that the progression of sepsis is attributed to redox imbalance and overproduction of proinflammatory cytokines. In previous studies, we have reported the anti-oxidative and anti-inflammatory effects of chitosan oligosaccharides in vitro. In the light of these findings, we applied the model of sepsis to mice by LPS injection to investigate whether chitosan oligosaccharides have a protective effect on LPS-induced sepsis. We found that treatment by chitosan oligosaccharides not only attenuated organ dysfunction but also improved survival rate after LPS injection. To further understand how it works, we examined several proinflammatory markers including neutrophil infiltration in organs and TNF-alpha and IL-1 beta in serum, and found that these cytokines were significantly reduced by chitosan oligosaccharide treatment. In addition to this, anti-oxidants including glutathione (GSH) and catalase (CAT) levels were depleted and malondialdehyde (MDA) levels were increased in LPS-induced sepsis, while chitosan oligosaccharides smoothed out the redox imbalance. Furthermore, we also assessed c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase signal activation by LPS-stimulation, and found both of them were attenuated by chitosan oligosaccharide treatment. Collectively, our data demonstrated that chitosan oligosaccharides can protect mice from the LPS challenge by virtue of anti-inflammatory effects as well as anti-oxidation properties, which might offer beneficial effects for patients with sepsis. (C) 2010 Elsevier B.V. All rights reserved.
关键词[WOS]: SEPTIC SHOCK ;  IN-VITRO ;  ENDOTOXIN-SHOCK ;  HYALURONIC-ACID ;  ANTIOXIDANT ;  SEPSIS ;  CHITOOLIGOSACCHARIDES ;  MODEL ;  KINASE ;  CELLS
语种: 英语
WOS记录号: WOS:000287065300016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115513
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dept Biotechnol, Dalian 116023, Liaoning, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Qiao, Ying,Bai, Xue-Fang,Du, Yu-Guang. Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2011,11(1):121-127.
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