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学科主题: 物理化学
题名: The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4
作者: Dang, Yibing1;  Li, Sheng1;  Wang, Wenxia2;  Wang, Shujing1;  Zou, Mingming1;  Guo, Yanjie1;  Fan, Jianhui1;  Du, Yuguang2;  Zhang, Jianing1
通讯作者: 杜昱光 ;  ZhangJN
关键词: Chitosan oligosaccharide ;  Spleen dendritic cell ;  TLR4 ;  Immune response
刊名: CARBOHYDRATE POLYMERS
发表日期: 2011-01-30
DOI: 10.1016/j.carbpol.2010.08.071
卷: 83, 期:3, 页:1075-1081
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 2,3
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
摘要: The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: To investigate the effects of chitosan oligosaccharide (COS) on dendritic cells (DCs) and the role of Toll-like receptor 4 (TLR4) in this immune process, Murine spleen CD11c(+) dendritic cells (SDCs) were isolated and cultured with S-COS and B-COS with polymeration degree of 3-7 and 7-16, respectively. The results showed that 8-COS up-regulated the expressions of MHCII and CD86 on SDCs, promoted the secretion of TNF-alpha from SDCs. SDCs treated with B-COS stimulated the proliferation of the CD4(+)T cells. However, these effects were not observed on SDCs treated with S-COS. Importantly, silencing the TLR4 expressions on SDCs by RNA interference approach attenuated the expression of CD86, MHCII on SDCs, and the secretion of TNF-alpha from SDCs, and the stimulating CD4(+)T cells proliferation capacity of SDCs induced by B-COS. These results suggest that B-COS, but not S-COS, promotes the activation of SDCs and TLR4 plays a bridge role in this process. (C) 2010 Elsevier Ltd. All rights reserved.
关键词[WOS]: RNA INTERFERENCE ;  IFN-GAMMA ;  IN-VIVO ;  DELIVERY ;  SUBSETS ;  MICE ;  OLIGOCHITOSAN ;  MATURATION ;  INHIBIT
语种: 英语
WOS记录号: WOS:000286965300005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115522
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Dept Biochem, Inst Glycobiol, Dalian 116044, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116001, Peoples R China

Recommended Citation:
Dang, Yibing,Li, Sheng,Wang, Wenxia,et al. The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4[J]. CARBOHYDRATE POLYMERS,2011,83(3):1075-1081.
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